{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:21:53Z","timestamp":1778826113124,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Amniotic fluid \u201csludge\u201d has been associated with an increased rate of spontaneous preterm delivery before 35\u00a0weeks, a higher frequency of clinical and histologic chorioamnionitis in a high\u2010risk population. Only one study evaluating the use of antibiotics in the presence of amniotic fluid \u201csludge\u201d showed reduced rates of spontaneous preterm birth at &lt;34\u00a0weeks. The objective of this study was to evaluate routine antibiotic treatment in the presence of amniotic fluid \u201csludge\u201d for prevention of preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A historically controlled observational study was performed between October 2010 and January 2015, including a total of 86 pregnant women with singleton pregnancies and the presence of amniotic fluid \u201csludge\u201d at ultrasound. Women admitted from October 2010 to September 2012 received no treatment with antibiotics, whereas those admitted from October 2012 to January 2015, received routinely clindamycin and first\u2010generation cephalosporin. The groups were compared considering the incidence of spontaneous preterm delivery. The effect of antimicrobials was also compared in the subgroup of women at high risk for spontaneous preterm birth (ie, cervical length\u00a0\u226425\u00a0mm, history of spontaneous preterm birth, previous spontaneous loss in the second trimester, Mullerian malformations or cervical conization).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antibiotic therapy reduced the incidence of spontaneous preterm birth at &lt;34\u00a0weeks (13.2% vs 38.5%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.047) in women at high\u2010risk for preterm birth, with an odds ratio of 0.24 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.06\u20100.99). Birthweight was significantly different between the study groups (2961\u00a0\u00b1\u00a0705 vs. 2554\u00a0\u00b1\u00a0819\u00a0g, respectively; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028), with no statistical significance for others variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that antibiotic treatment in high\u2010risk pregnant women with amniotic fluid \u201csludge\u201d can be effective in the reduction of the frequency of spontaneous preterm delivery and can increase the birthweight.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13603","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T21:31:51Z","timestamp":1551821511000},"page":"1157-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Antibiotic treatment for patients with amniotic fluid \u201csludge\u201d to prevent spontaneous preterm birth: A historically controlled observational study"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-533X","authenticated-orcid":false,"given":"Alan Roberto","family":"Hatanaka","sequence":"first","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine (UNIFESP \u2010 EPM) Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Santucci","family":"Franca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine (UNIFESP \u2010 EPM) Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Emy Nishimoto Kawanami","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine (UNIFESP \u2010 EPM) Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliam Cristine","family":"Rolo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine (UNIFESP \u2010 EPM) Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosiane","family":"Mattar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine (UNIFESP \u2010 EPM) Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Fernandes","family":"Moron","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine (UNIFESP \u2010 EPM) Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo 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