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The outcomes explored were: associated anomalies detected at follow\u2010up ultrasound examination; fetal magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and birth; chromosomal abnormalities detected with standard and chromosomal microarray analysis, intrauterine, neonatal, and perinatal death, and termination of pregnancy; rate of surgical and nonsurgical treatment; neurodevelopmental outcome; and false\u2010positive rate of prenatal diagnosis. Meta\u2010analyses of proportions were used to combine data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five studies (1567 fetuses) were included. Associated anomalies were detected in 7.8% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.1%\u201029.3%) of cases at follow\u2010up ultrasound, and in 4.0% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.1%\u201013.2%) of cases, fetal <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> identified anomalies not detected at ultrasound assessment. Similarly, 7.0% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.4%\u201011.7%) of cases labeled as isolated talipes on prenatal imaging were found to have associated anomalies at birth. Abnormal karyotype was present in 3.6% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.7%\u20106.2%) of fetuses, whereas no anomaly was found at chromosomal microarray analysis, although this outcome was reported by only 1 study. Intrauterine death occurred in 0.99% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.4%\u20101.9%) of fetuses, whereas the corresponding figures for neonatal death and termination of pregnancy were 1.5% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.6%\u20102.6%) and 2.2% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2%\u20103.4%), respectively. Surgical management of anomalies after birth was found in 41.7% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 27.0%\u201057.2%) of fetuses with isolated talipes, and 54.8% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 31.5%\u201077.0%) had nonsurgical management of the anomalies after birth. Abnormal neurodevelopmental outcome was reported in 7.6% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0%\u201019.4%) of children, although this analysis was affected by the small number of included cases and short time of follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Isolated talipes detected on prenatal ultrasound carries a generally good prognosis. The incidence of additional abnormalities detected on fetal <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, aneuploidy, or neurodevelopmental disability is relatively low. However, longitudinal ultrasound assessment during pregnancy and a thorough postnatal evaluation are recommended to rule out associated anomalies that may significantly impact short\u2010 and long\u2010term prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13637","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:17:49Z","timestamp":1556673469000},"page":"1367-1377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Outcome of isolated fetal talipes: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-3393","authenticated-orcid":false,"given":"Daniele","family":"Di Mascio","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-7407","authenticated-orcid":false,"given":"Danilo","family":"Buca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Saint George's Hospital London UK"},{"name":"Vascular Biology Research Center, Molecular and Clinical Sciences Research Institute St George's University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Division of Maternal and Fetal Medicine Ospedale Cristo Re University of Rome Tor Vergata Rome Italy"},{"name":"Department of Obstetrics and Gynecology I.M. 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