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This narrative review set out to identify (1) new evidence that may support routine use of pain management strategies for <jats:styled-content style=\"fixed-case\">IUC<\/jats:styled-content> placement; (2) procedure\u2010related approaches that may have a positive impact on the pain experience; and (3) factors that may help healthcare professionals identify women at increased risk of pain with <jats:styled-content style=\"fixed-case\">IUC<\/jats:styled-content> placement. A literature search of the PubMed and Cochrane library databases revealed 550 citations, from which we identified 43 new and pertinent studies for review. Thirteen randomized clinical trials, published since 2012, described reductions in placement\u2010related pain with administration of oral and local analgesia (oral ketorolac, local analgesia with different lidocaine formulations) and cervical priming when compared with placebo or controls. Four studies suggested that ultrasound guidance, balloon dilation, and a modified placement device may help to minimize the pain experienced with <jats:styled-content style=\"fixed-case\">IUC<\/jats:styled-content> placement. Eight publications suggested that previous cesarean delivery, timing of insertion relative to menstruation, dysmenorrhea, expected pain, baseline anxiety, and size of insertion tube may affect the pain experienced with <jats:styled-content style=\"fixed-case\">IUC<\/jats:styled-content> placement. Oral and local analgesia and cervical priming can be effective in minimizing <jats:styled-content style=\"fixed-case\">IUC<\/jats:styled-content> placement\u2010related pain when compared with placebo, but routine use remains subject for debate. Predictive factors may help healthcare professionals to identify women at risk of experiencing pain. Targeted use of effective strategies in these women may be a useful approach while research continues in this area.<\/jats:p>","DOI":"10.1111\/aogs.13662","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T23:38:48Z","timestamp":1558481928000},"page":"1500-1513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Interventions for the prevention of pain associated with the placement of intrauterine contraceptives: An updated review"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1444","authenticated-orcid":false,"given":"Kristina","family":"Gemzell\u2010Danielsson","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet WHO\u2010Center Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey 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