{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:19:33Z","timestamp":1791231573384,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Antiphospholipid syndrome is a chronic autoimmune disease with a high prevalence in females. Published data have identified that antiphospholipid antibodies (<jats:styled-content style=\"fixed-case\">APLA<\/jats:styled-content>) of antiphospholipid syndrome are risk factors for poor pregnancy outcomes, such as recurrent spontaneous abortion, intrauterine growth restriction and preeclampsia. However, the association between <jats:styled-content style=\"fixed-case\">APLA<\/jats:styled-content> and late fetal loss is not fully understood and remains controversial. The aim of this study is to identify and analyze the recent publications to better understand the association between <jats:styled-content style=\"fixed-case\">APLA<\/jats:styled-content> and late fetal loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The literature was searched on 31 January 2019 using Ovid, <jats:styled-content style=\"fixed-case\">Medline<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and the Cochrane Central Register of Controlled Trials (<jats:styled-content style=\"fixed-case\">CENTRAL<\/jats:styled-content>) to evaluate the association between <jats:styled-content style=\"fixed-case\">APLA<\/jats:styled-content> and late fetal loss, with articles published before January 2019, according to the <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> statement. Without imposing regional restrictions, referenced articles were selected. Quality assessment was conducted independently by two reviewers, based on the Newcastle\u2010Ottawa scale. For the meta\u2010analysis, we used odds ratios (random effects model). The between\u2010study heterogeneity was assessed by <jats:italic>Q<\/jats:italic> test. Publication bias was assessed by funnel plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen studies (with 10\u00a0265 cases) were included in the final analysis. The odds ratio (OR) for the late fetal loss with lupus anticoagulant was 5.02 (95% confidence interval [CI] 2.14\u20107.89). Seven included studies reported that lupus anticoagulant had a statistically significant association with late fetal loss. The results did not show a statistically significant association between anticardiolipin antibodies and late fetal loss. The pooled odds ratio for the association of anticardiolipin antibodies with late fetal loss was 3.47 (95% CI 0.68\u20106.26). However, we did find the relation between anticardiolipin antibodies and late fetal loss among cohort studies (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.27, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.20\u20103.44). Anti\u2010beta2 glycoprotein 1 antibodies (\u03b22<jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>1) showed a significant association with late fetal loss (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.13, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.75\u20105.50).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lupus anticoagulant is strongly associated with late fetal loss in antiphospholipid syndrome patients. However, the association between anticardiolipin antibodies and late fetal loss is inconsistent. There are currently insufficient data to support a significant relation between \u03b22<jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>1 and late fetal loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13665","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T10:11:11Z","timestamp":1558951871000},"page":"1523-1533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The association between antiphospholipid antibodies and late fetal loss: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"98","author":[{"given":"Jinfeng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital of Sichuan University the Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University Ministry of Education Chengdu Sichuan China"},{"name":"West China School 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