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To improve recommendations for optimal identification, management, and treatment, publications on opioids in pregnancy were reviewed. Published literature from 2007 to 2017 was searched in PubMed, Cochrane and Embase databases. The review employed 60 publications from 210 studies identified, that were of varying quality and included randomized controlled trials, systematic reviews, meta\u2010analyses, and Cochrane reviews. The prevalence of opioid use in pregnancy is underestimated. Screening by urine testing and self\u2010reporting is acceptable to identify fetal exposure. To minimize risk, opioid agonist pharmacotherapy should replace the continued use of opioids or detoxification. Current guidelines recommend methadone and buprenorphine equally. However, recent studies indicate that buprenorphine has advantages over methadone. Accordingly, we suggest buprenorphine as first\u2010line therapy. Future studies should elaborate on better objective screening methods to prevent the consequences of fetomaternal opioid exposure.<\/jats:p>","DOI":"10.1111\/aogs.13677","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T07:39:51Z","timestamp":1560497991000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Management and monitoring of opioid use in pregnancy"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1662-3547","authenticated-orcid":false,"given":"Nete Lundager Klokker","family":"Rausgaard","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics University of Southern Denmark Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge Olga","family":"Ibsen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University of Southern Denmark Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University of Southern Denmark Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-2826","authenticated-orcid":false,"given":"Ronald Francis","family":"Lamont","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University of Southern Denmark Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-1121","authenticated-orcid":false,"given":"Pernille","family":"Ravn","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University of Southern Denmark Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"Substance\u2010Related and Addictive Disorders, Opioid\u2010Related Disorders","year":"2013"},{"key":"e_1_2_9_3_1","volume-title":"A Collaborative Approach to the Treatment of Pregnant Women With Opioid Use Disorders","author":"SAMHSA","year":"2016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13462"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002235"},{"key":"e_1_2_9_6_1","first-page":"CD006318","article-title":"Maintenance agonist treatments for opiate dependent pregnant women","volume":"2","author":"Minozzi S","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.3951"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12528"},{"key":"e_1_2_9_9_1","volume-title":"Substance Use. 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