{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:18Z","timestamp":1787013858284,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2019,12]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n In 2008, Hult\u00e9n et\u00a0al hypothesized that maternal ovarian trisomy 21 mosaicism might be the primary causative factor for fetal Down syndrome. We hypothesize that this theory can be extended to trisomy 13.<\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n We collected fetal ovarian tissue from seven female fetuses between 16 and 23 gestational weeks, following the termination of the pregnancy for non\u2010genetic reasons. All procedures were performed with informed consent and ethical approval from the local ethics committee. We used touch preparation techniques from fetal ovarian tissues and an anti\u2010stromal antigen 3 antibody against the meiosis\u2010specific stromal antigen 3 protein to differentiate between germ cells, ovarian stromal cells and the cells entering their first meiotic prophase. We used fluorescence in situ hybridization analysis to determine chromosome 13 numbers in each cell.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We were able to detect a proportion of trisomy 13 cells in all cases. The average incidence of trisomy 13 cells was 2.04% in stromal antigen 3\u2010positive and 0.91% in the stromal antigen 3\u2010negative cells. The number of the trisomic cells increased significantly with gestational age (for stromal antigen 3\u2010positive cells\n r<\/jats:italic>\n \u00a0=\u00a00.93,\n P<\/jats:italic>\n \u00a0=\u00a00.0038, for stromal antigen 3\u2010negative cells\n r<\/jats:italic>\n \u00a0=\u00a00.85,\n P<\/jats:italic>\n \u00a0=\u00a00.0071).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study indicates that besides trisomy 21, the Oocyte Mosaicism Selection model could be extended to trisomy 13 as well. The crucial factor for trisomy 13 seems to be the pre\u2010meiotic\/mitotic trisomy 13 mosaicism, leading to a so\u2010called secondary meiotic nondisjunction of those oocytes having three copies of chromosome 13.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aogs.13694","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T05:48:51Z","timestamp":1567057731000},"page":"1558-1564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evidence for the Oocyte Mosaicism Selection model on the origin of Patau syndrome (trisomy 13)"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-0325","authenticated-orcid":false,"given":"Lilla \u00c9.","family":"Babay","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Uzsoki Hospital Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"Hor\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology P\u00e9terffy S\u00e1ndor Street Hospital Clinic and Trauma Center Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Gy\u0151rffy","sequence":"additional","affiliation":[{"name":"MTA TTK Lend\u00fclet Cancer Biomarker Research Group Budapest Hungary"},{"name":"2nd Department of Pediatrics Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyula R.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Baross Street Division Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)90676-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.18.120184.000441"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"288","article-title":"Patau syndrome with a long survival. A case report","volume":"3","author":"Duarte AC","year":"2004","journal-title":"Genet Mol Res"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"On the origin of trisomy 21 Down syndrome","volume":"18","author":"Hult\u00e9n MA","year":"2008","journal-title":"Mol Cytogenet"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-09-0088"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063045"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00210736"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm3010167"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12238"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12400"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpradiol.2014.04.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31913"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004120000088"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3885"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3958"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0683"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.03.024"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2012.08.040"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.13694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.13694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:15:26Z","timestamp":1694045726000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,29]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/aogs.13694"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13694","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,29]]},"assertion":[{"value":"2019-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}