{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:42:13Z","timestamp":1784634133529,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010600","name":"Tays","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Intrahepatic cholestasis of pregnancy (ICP) is a reversible liver disorder occurring during pregnancy. It has a typical genetic background with known genetic mutations and can be considered an expression of this genetic predisposition. The objective of this study was to determine whether ICP is associated with specific long\u2010term comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study population comprised 571 women with ICP in at least one pregnancy who were compared with 1333 pregnant women without ICP during 1969\u20101988 at Tampere University Hospital, Finland. The cohort's follow\u2010up time was 44\u00a0years. All ICD\u201010 classification discharge diagnoses were examined for the women in the ICP group from 1998 to 2013 and ICD\u201010 diagnoses from outpatient care from 1969 to 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At least one disease of the digestive system had been diagnosed in 50.4% (288\/571) of the ICP mothers compared with 34.4% (459\/1333) of the reference group (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). In a more detailed analysis, women with a history of ICP had an increased risk for cholelithiasis and\/or cholecystitis (odds ratio [OR] 2.88, 95% confidence interval [CI] 2.17 to 3.84), diseases of the pancreas (OR 2.26, 95% CI 1.20 to 4.27) and hypothyroidism (OR 2.38, 95% CI 1.27 to 4.46) compared with the reference group. Arterial diseases were less common in the ICP mothers than in the reference group (OR 0.38, 95% CI .15 to .99). Regarding other diseases, there were no statistically significant differences between the ICP mothers and reference group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Half of the women with a history of ICP were diagnosed with at least one disease of the digestive system compared with a third in the reference group. The risk of cholelithiasis, cholecystitis, diseases of the pancreas and hypothyroidism was increased compared with the reference group. These are important facts when counseling women after a pregnancy with ICP. Also, this is of importance for the general practitioners and other physicians who take care of these women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13695","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T14:37:49Z","timestamp":1564411069000},"page":"1534-1539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Intrahepatic cholestasis of pregnancy and comorbidity: A 44\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7077-0540","authenticated-orcid":false,"given":"Suvi\u2010Tuulia","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"first","affiliation":[{"name":"Department of General Practice Faculty of Medicine and Health Technology Tampere University Tampere Finland"},{"name":"Janakkala Health Center Turenki Finland"},{"name":"Science Center Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-1201","authenticated-orcid":false,"given":"Kaisa","family":"Turunen","sequence":"additional","affiliation":[{"name":"Department of General Practice Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-5557","authenticated-orcid":false,"given":"Kari J.","family":"Mattila","sequence":"additional","affiliation":[{"name":"Department of General Practice Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Kosunen","sequence":"additional","affiliation":[{"name":"Department of General Practice Faculty of Medicine and Health Technology Tampere University Tampere Finland"},{"name":"Center for General Practice Pirkanmaa Hospital District Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-2634","authenticated-orcid":false,"given":"Markku","family":"Sumanen","sequence":"additional","affiliation":[{"name":"Department of General Practice Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i23.7134"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000346"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21111"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2012.01403.x"},{"key":"e_1_2_9_7_1","first-page":"2","article-title":"Intrahepatic cholestasis of pregnancy and cancer: a cohort study","volume":"6","author":"H\u00e4m\u00e4l\u00e4inen S","year":"2017","journal-title":"Fam Med Sci Res"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12174"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2013.10.087"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60731-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02813431003784001"},{"key":"e_1_2_9_12_1","unstructured":"The National Institute for Health and Welfare in Finland.https:\/\/thl.fi\/en\/web\/thlfi-en\/statistics\/information-on-statistics\/register-descriptions\/care-rebgister\u2010for\u2010health\u2010care. 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