{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:46:59Z","timestamp":1793879219875,"version":"4.7.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Uterine artery embolization (UAE) has been gaining increasing popularity as an effective and minimally invasive treatment for uterine fibroids. However, there has been growing concern over the risk of unintended embolization of the utero\u2010ovarian circulation, leading to reduction of ovarian blood supply with subsequent impairment of ovarian reserve. The purpose of this study was to investigate the impact of UAE on circulating anti\u2010M\u00fcllerian hormone (AMH) and other markers of ovarian reserve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      This meta\u2010analysis included all published cohort, cross\u2010sectional and case\u2010control studies, as well as randomized trials that investigated the impact of UAE on circulating AMH. Data sources included MEDLINE, EMBASE, Dynamed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov and the Cochrane Library from January 2000 to June 2019. All identified articles were screened, and articles were selected based on the inclusion and exclusion criteria. AMH and other data were extracted from the eligible articles and entered into\n                      <jats:sc>RevMan<\/jats:sc>\n                      software to calculate the weighted mean difference between pre\u2010 and post\u2010embolization values. PROSPERO registration number: CRD42017082615.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This review included 3 cohort and 3 case\u2010control studies (n\u00a0=\u00a0353). The duration of follow up after UAE ranged between 3 and 12\u00a0months. Overall pooled analysis of all studies showed no significant effect of UAE on serum AMH levels (weighted mean difference \u20130.58\u00a0ng\/mL; 95% CI \u20131.5 to 0.36,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a095%). Subgroup analysis according to age of participants (under and over 40\u00a0years) and according to follow\u2010up duration (3, 6 and 12\u00a0months) showed no significant change in post\u2010embolization circulating AMH. Pooled analysis of serum follicle\u2010stimulating hormone (FSH) concentrations (4 studies, n\u00a0=\u00a0248) revealed no statistically significant change after UAE (weighted mean difference 4.32; 95% CI \u20130.53 to 9.17;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a095%). Analysis of 2 studies (n\u00a0=\u00a062) measuring antral follicle count showed a significant decline at 3\u2010month follow up (weighted mean difference \u20133.28; 95% CI \u20135.62 to \u20130.93;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a094%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Uterine artery embolization for uterine fibroids does not seem to affect ovarian reserve as measured by serum concentrations of AMH and FSH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.13698","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T18:28:20Z","timestamp":1564684100000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["The impact of uterine artery embolization on ovarian reserve: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"99","author":[{"given":"Tarek","family":"El Shamy","sequence":"first","affiliation":[{"name":"Derby Fertility Unit University Hospitals of Derby and Burton NHS Foundation Trust Derby UK"},{"name":"West Middlesex University Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8321-1302","authenticated-orcid":false,"given":"Saad A. 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