{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:12:04Z","timestamp":1778947924348,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Preterm birth is a major cause of neonatal morbidity and mortality. There is an urgent need to accurately predict imminent delivery to enable necessary interventions such as tocolytic, glucocorticoid, and magnesium sulfate administration. We aimed to evaluate placental \u03b1\u2010macroglobulin\u20101 as a new diagnostic marker in the prediction of preterm birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We performed a prospective observational trial in women with intact membranes between 24<jats:sup>+0<\/jats:sup> and 36<jats:sup>+6<\/jats:sup> weeks of gestation. We included both women with and without threatened preterm labor symptoms. We evaluated the test performance of placental \u03b1\u2010macroglobulin\u20101 measurements in cervicovaginal fluid regarding three different presentation\u2010to\u2010delivery intervals: \u22642, \u22647, \u226414\u00a0days. In addition, we calculated placental \u03b1\u2010macroglobulin\u20101 performance in combination with other prognostic factors such as ultrasonographic cervical length measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 126 women in the study. We detected high specificity (97%\u201098%) and negative predictive value (89%\u201097%) for placental \u03b1\u2010macroglobulin\u20101 at all time intervals. We assessed placental \u03b1\u2010macroglobulin\u20101 in combination with cervical length measurements (\u226415\u00a0mm) in the sub\u2010group of women presenting with threatened preterm labor symptoms (n\u00a0=\u00a063) and detected high positive predictive values (100%) for 7\u2010 and 14\u2010day presentation\u2010to\u2010delivery intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study provides evidence that placental \u03b1\u2010macroglobulin\u20101 testing in cervicovaginal fluid, in combination with cervical length measurements, accurately predicts preterm birth in women with preterm labor symptoms. This novel test combination may be used clinically to triage women presenting with threatened preterm labor, avoiding overtreatment and unnecessary hospitalizations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13744","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T08:59:40Z","timestamp":1570352380000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cervico\u2010vaginal placental \u03b1\u2010macroglobulin\u20101 combined with cervical length for the prediction of preterm birth in women with threatened preterm labor"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-2761","authenticated-orcid":false,"given":"Anda\u2010Petronela","family":"Radan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Bern and University of Bern Bern 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