{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:08Z","timestamp":1747183208152,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients diagnosed with cervical cancer face several treatment options, depending on the physical examination and the imaging modality results. Transvaginal sonography (TVS) was proposed as an imaging option to determine local spread of cervical tumors, along with magnetic resonance imaging, also by recently released International Federation of Gynecology and Obstetrics recommendations. We examined whether combined data from physical examination, high\u2010detail TVS, and positron emission tomography with <jats:sup>18<\/jats:sup>F\u2010labeled fluoro\u20102\u2010deoxyglucose and computed tomography (<jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT) may contribute to triage efficiency of cervical cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This is a retrospective study of consecutive women diagnosed with cervical cancer at the Carmel Health Center, Haifa, Israel, during 2010\u20102015. Inclusion criteria were histology of cervical cancer and the availability of three modalities\u2014a thorough physical examination, a high\u2010detail TVS, and positron emission tomography (PET) with <jats:sup>18<\/jats:sup>F\u2010FDG and computed tomography (<jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT). End points were the possibility to predict local invasion to the parametrium and distant lymph node metastasis at the time of triage to surgery or chemoradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three patients with cervical cancer were evaluated. TVS correctly predicted no involvement of the parametrium for the 25 who had a postoperative pathological report. TVS measurement of tumor dimension was also matched by the pathological report in these cases. Only three patients were referred for adjuvant therapy according to postoperative pathology criteria. Among 43 women treated with a combination of chemotherapy and radiotherapy due to advanced disease, and with complete data, at least two modalities were congruent with chemoradiation for 33 (77%). Three patients (7%) were referred to chemoradiation due to TVS result alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of high\u2010detail TVS, directed to predict tumor dimensions and local spread, performed by a trained operator, combined with <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT and physical examination, can assist in selecting optimal treatment for cervical cancer patients, thus avoiding unnecessary operations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13750","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T18:25:00Z","timestamp":1571509500000},"page":"312-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The added benefit of transvaginal sonography in the clinical staging of cervical 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