{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T03:04:51Z","timestamp":1788059091785,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We aimed to assess if maximum velocities of the ductus venosus flow velocity waveform are associated with adverse outcomes in early\u2010onset fetal growth restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Retrospective cohort study from two tertiary referral units, including singleton fetuses with estimated birthweight or fetal abdominal circumference \u226410th centile and absent or reversed end\u2010diastolic velocity in the umbilical artery delivered between 26<jats:sup>+0<\/jats:sup> and 34<jats:sup>+0<\/jats:sup>\u00a0weeks of gestation. Pulsatility index for veins, and maximum velocities of S\u2010, D\u2010, v\u2010 and a\u2010waves, were measured in the ductus venosus within 24\u00a0hours of birth. Logistic regression was used to describe the relation between severe neonatal morbidity or neonatal death and clinical independent predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 132 early\u2010onset fetal growth restriction fetuses. Newborns with neonatal morbidity or neonatal death had significantly lower values of v\/D maximum velocity ratio multiples of the median (0.86 vs 095; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) within 24\u00a0hours of birth. The v\/D ratio remained a significant predictor of neonatal death or severe neonatal morbidity after adjusting for gestational age and birthweight (adjusted odds ratio 0.065, 95% confidence interval 0.004\u20100.957).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Assessment of ductus venosus v\/D maximum velocity ratio might help to identify fetal growth restriction fetuses at increased risk for neonatal death or severe neonatal morbidity. Confirmation in prospective studies is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13782","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:07:33Z","timestamp":1575281253000},"page":"608-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ductus venosus Doppler waveform pattern in fetuses with early growth restriction"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-1793","authenticated-orcid":false,"given":"Nicola","family":"Fratelli","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology ASST Spedali Civili di Brescia and University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Amighetti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology ASST Spedali Civili di Brescia and University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2393-7501","authenticated-orcid":false,"given":"Amar","family":"Bhide","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust and Molecular &amp; Clinical Sciences Research Institute St George's University London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-0823","authenticated-orcid":false,"given":"Anna","family":"Fichera","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology ASST Spedali Civili di Brescia and University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-7670","authenticated-orcid":false,"given":"Asma","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust and Molecular &amp; Clinical Sciences Research Institute St George's University London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-2232","authenticated-orcid":false,"given":"Aris T.","family":"Papageorghiou","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust and Molecular &amp; Clinical Sciences Research Institute St George's University London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-714X","authenticated-orcid":false,"given":"Federico","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology ASST Spedali Civili di Brescia and University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5531-4301","authenticated-orcid":false,"given":"Basky","family":"Thilaganathan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust and Molecular &amp; Clinical Sciences Research Institute St George's University London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00614.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62049-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18815"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13572"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8903"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5386"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00590.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00123-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253215.79121.75"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2002.00627.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.566"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.226"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10151"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13242"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12811"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13207"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04010034.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04050381.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12371"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11082"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13190"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.2.329"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106753"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7347"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4537"},{"issue":"254","key":"e_1_2_9_28_1","first-page":"e251","article-title":"Cardiac dysfunction and cell damage across clinical stages of severity in growth\u2010restricted fetuses","volume":"199","author":"Crispi F","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.02.044"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2008.27.9.1283"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17433"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20354"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338003"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.13782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:32:57Z","timestamp":1694079177000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,22]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/aogs.13782"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13782","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,22]]},"assertion":[{"value":"2019-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}