{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:34:38Z","timestamp":1775018078032,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Intramuscular or intravenous oxytocin is used in out\u2010of\u2010hospital emergency care in Finland to prevent postpartum hemorrhage after unplanned out\u2010of\u2010hospital deliveries. However, the use of oxytocin by emergency medical services is based on in\u2010hospital studies. The aim of this study was to determine whether the use of oxytocin is associated with diminished postpartum hemorrhage after unplanned out\u2010of\u2010hospital deliveries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We studied patient records covering all unplanned out\u2010of\u2010hospital deliveries in the Helsinki University Hospital area between 1 January 2013 and 31 December 2017 inclusive. Oxytocin was available in ambulances responsible for half of the population of the study area and was not available in ambulances responsible for the other half. The study area corresponded to 25% of all deliveries in Finland. The primary outcome was the estimated total bleeding (mL). Secondary outcomes were (1) the first blood hemoglobin value measured in hospital (g\/L), (2) whether blood hemoglobin was measured during the first 24\u00a0hours after delivery, (3) the need for red blood cell concentrate, (4) the need for uterotonic or prothrombotic medication in\u2010hospital during the first 24\u00a0hours, (5) the need for any postpartum operation during the first 24\u00a0hours and (6) composite outcome combining the secondary outcomes 2\u20105.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all ambulance responses in the study area, .04% concerned out\u2010of\u2010hospital deliveries. There were 216 analyzed out\u2010of\u2010hospital deliveries. Altogether, 111 of these occurred in the area with oxytocin available in ambulances and 105 in the area without. Oxytocin was administered in 57 of the 111 deliveries (51%) where it was available. No differences in the primary outcome (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.548 for oxytocin available vs not available and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.381 for oxytocin used vs not used) or secondary outcomes were detected between those deliveries where oxytocin was available vs not available or between those where it was used vs not used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Out\u2010of\u2010hospital oxytocin was not associated with diminished postpartum hemorrhage in this study setting. Oxytocin does not seem to be an essential drug for all ambulance units. The in\u2010hospital use of oxytocin was not evaluated and thus is not disputed by this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13804","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T13:35:25Z","timestamp":1579008925000},"page":"901-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of oxytocin in prevention of postpartum hemorrhage in unplanned out\u2010of\u2010hospital deliveries treated by emergency medical services"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2096-6366","authenticated-orcid":false,"given":"Emma","family":"Klemettil\u00e4","sequence":"first","affiliation":[{"name":"Division of Anesthesiology Department of Anesthesiology, Intensive Care and Pain Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-6917","authenticated-orcid":false,"given":"Leena","family":"Rahkonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Nuutila","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0636-6567","authenticated-orcid":false,"given":"Mitja","family":"L\u00e4\u00e4peri","sequence":"additional","affiliation":[{"name":"Department of Emergency Care and Services University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-4553","authenticated-orcid":false,"given":"Heini","family":"Harve-Ryts\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"Department of Emergency Care and Services University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization.WHO recommendations for the prevention and treatment of postpartum haemorrhage; 2018 Update Uterotonics for the prevention of postpartum haemorrhage. Geneva:WHO;2018. Available online at:https:\/\/www.who.int\/reproductivehealth\/publications\/maternal_perinatal_health\/9789241548502\/en\/. Accessed January 7 2019."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340903214940"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-016-0285-5"},{"key":"e_1_2_10_6_1","unstructured":"National Institute for Health and Welfare. Available from:https:\/\/thl.fi\/en\/web\/thlfi-en\/statistics\/statistics-by-topic\/sexual-and-reproductive-health\/parturients-deliveries-and-births\/perinatal-statistics-parturients-delivers-and-newborns. Accessed 6 January 2019."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12450"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1617-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1638-4"},{"key":"e_1_2_10_10_1","first-page":"1","article-title":"Tranexamic acid for treatment of primary postpartum hemorrhage after vaginal delivery: a systematic review and meta\u2010analysis of randomized controlled trials","volume":"10","author":"Della Corte L","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30638-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1322-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2018.8.39336"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.13804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.13804","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T06:50:23Z","timestamp":1693983023000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,28]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/aogs.13804"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13804","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,28]]},"assertion":[{"value":"2019-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}