{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:07:46Z","timestamp":1787238466427,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Noninvasive prenatal testing (NIPT) has become a popular screening test for the most common fetal aneuploidies. The performance of NIPT is affected by several factors including maternal obesity, which results in a greater rate of no\u2010calls for obese pregnant women. Guidelines regarding NIPT in prenatal screening have been published, but with few and divergent recommendations on the issue. We aimed to review the medical literature, guidelines from scientific societies and information material from commercial NIPT providers on no\u2010calls and maternal obesity. We systematically identified medical literature and guidelines from scientific societies using the database MEDLINE. Information material from commercial NIPT providers was found via a systematic search on Google.com. Nine medical studies investigating the association between maternal obesity and NIPT no\u2010calls were included. They all showed the same trend: increasing no\u2010call rate with increasing maternal obesity. The no\u2010call rate ranged from 0% to 4.2% for women with body mass index (BMI) 18.5\u201024.9 and from 5.4% to 70.1% for women BMI \u226540. We identified 17 scientific societies with guidelines and 13 commercial NIPT providers. All were checked for information material on no\u2010calls and maternal obesity. To allow comparison, all guidelines were examined to answer the same three predefined questions. Of the 17 included scientific societies, 13 (76.5%) mentioned the association between maternal obesity and NIPT no\u2010calls, two (11.8%) specified weight limits and three (17.6%) advised against NIPT for severely obese pregnant women. None of the 13 commercial NIPT providers provided specific recommendations, but four (30.8%) cite maternal obesity as a potential cause for a no\u2010call. Because of the increasing number of patients in this group, we advocate updated recommendations to guide decision making in prenatal screening for obese pregnant women.<\/jats:p>","DOI":"10.1111\/aogs.13848","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T17:42:02Z","timestamp":1584553322000},"page":"744-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Noninvasive prenatal testing and maternal obesity: A review"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-5939","authenticated-orcid":false,"given":"Laura A.","family":"Juul","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynecology Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Hvidovre Hospitals NIPT Center Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-5947","authenticated-orcid":false,"given":"Tanja S.","family":"Hartwig","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynecology Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Hvidovre Hospitals NIPT Center Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-4049","authenticated-orcid":false,"given":"Louise","family":"Ambye","sequence":"additional","affiliation":[{"name":"Hvidovre Hospitals NIPT Center Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9766-5820","authenticated-orcid":false,"given":"Steen","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Hvidovre Hospitals NIPT Center Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-5407","authenticated-orcid":false,"given":"Finn S.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynecology Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Hvidovre Hospitals NIPT Center Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2637"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1871-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4126"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4119"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"Cell\u2010free fetal DNA in the early and late first trimester","volume":"18","author":"Miltoft CB","year":"2019","journal-title":"Fetal Diagn Ther"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12331"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.04.042"},{"key":"e_1_2_9_10_1","volume-title":"Poster Presented at: American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting 2016","author":"Wardrop J","year":"2016"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.08.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.207951"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4625"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002752"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.01.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2012.138"},{"key":"e_1_2_9_17_1","unstructured":"WHO.Obesity and Overweight. WHO.2018. Available online at:https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight(accessed 3 September 2019)."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17562"},{"key":"e_1_2_9_19_1","volume-title":"1. Trimester skanning inkl. nakkefoldskanning og risikovurdering for kromosomsygdom. F\u00d8TO\u2010Sandbjerg guideline 2018. [First trimester scan incl. nuchal translucency scan and risk assessment for chromosome disease]","author":"Petersen OB","year":"2018"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.01.032"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.03.043"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.97"},{"issue":"2","key":"e_1_2_9_23_1","first-page":"176","article-title":"DEGUM, \u00d6GUM, SGUM and FMF Germany Recommendations for the implementation of first\u2010trimester screening, detailed ultrasound, cell\u2010free DNA screening and diagnostic procedures","volume":"40","author":"Kozlowski P","year":"2018","journal-title":"Ultraschall Medizin"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19176"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002728"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2019.07.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4608"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.57"},{"key":"e_1_2_9_29_1","unstructured":"BeSHG Prenatal Committee.NIPT good clinical practice guidelines.2017. Available online at:http:\/\/www.beshg.be\/index.php?page=about%0AAllPapers\/B\/BelgianSocietyforHumanGenetics2017\u2010NIPTgoodclinicalpracticeguidelines.pdf(accessed at 30 October 2019)"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1553804"},{"issue":"15","key":"e_1_2_9_31_1","first-page":"1","article-title":"Non\u2010invasive prenatal testing for chromosomal abnormality using maternal plasma DNA","volume":"15","author":"Soothill P","year":"2014","journal-title":"R Coll Obstet Gynaecol"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17483"},{"key":"e_1_2_9_33_1","unstructured":"Information about screening for Down syndrome Edwards' syndrome and Patau's syndrome. Prenatal Screening.The Hague Netherlands:National Institute for Public Health and the Environment 2017. Availiabe athttps:\/\/www.rivm.nl\/down\u2010edwards\u2010patau\/folder(accessed 30 October 2019)"},{"key":"e_1_2_9_34_1","volume-title":"Analys av foster\u2010DNA i kvinnans blod: icke\u2010invasiv fosterdiagnostik (NIPT) f\u00f6r trisomi 13, 18 och 21. [Analysis of fetal DNA in maternal blood: Non\u2010invasive prenatal diagnostics (NIPT) for trisomy 13, 18 and 21]","author":"Svensk F\u00f6rening f\u00f6r Obstetrik & Gynekologi [SFOG. Swedish Society of Obstetrics and Gynecology]","year":"2016"},{"key":"e_1_2_9_35_1","unstructured":"HaugenG BlaasHK Braaten\u00d8 SandeR.Prenatal diagnostikk [Prenatal diagnostics]. Nor Gynekol Foren [Norwegian Soc Gynecol]; (Vejleder i F\u00f8dselshjelp (2014) [Recommendation on Maternity Aid]). Availiable online at:https:\/\/www.legeforeningen.no\/foreningsledd\/fagmed\/norsk\u2010gynekologisk\u2010forening\/veiledere\/veileder\u2010i\u2010fodselshjelp\u20102014\/5.\u2010prenatal\u2010diagnostikk\/(accessed 30 October 2019)"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.05.009"},{"issue":"5","key":"e_1_2_9_37_1","first-page":"123","article-title":"Practice Bulletin No. 163: screening for fetal","volume":"127","author":"Rose NC","year":"2016","journal-title":"Aneuploidy"},{"key":"e_1_2_9_38_1","volume-title":"DNA\u2010based Noninvasive Prenatal Testing for Fetal Aneuploidy","author":"Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG)","year":"2015"},{"key":"e_1_2_9_39_1","unstructured":"Natera.Panorama. Available online at:https:\/\/www.natera.com\/panorama\u2010test\/clinical\u2010information(accessed 25 February 2020)."},{"key":"e_1_2_9_40_1","unstructured":"Roche.Harmony. Available online at:https:\/\/harmonytest.com\/en\/clinicians.html(accessed 26 February 2020)."},{"key":"e_1_2_9_41_1","unstructured":"Illumina.Verifi. Available online at:https:\/\/emea.illumina.com\/clinical\/illumina_clinical_laboratory\/verifi\u2010prenatal\u2010tests.html?langsel=\/dk\/(accessed 24 February 2020)."},{"key":"e_1_2_9_42_1","unstructured":"Integrated Genetics.MaterniT21. Available online at:https:\/\/www.integratedgenetics.com\/providers\/tests\/prenatal(accessed 25 February 2020)."},{"key":"e_1_2_9_43_1","unstructured":"Quest Diagnostics.QNatal. Available online at:https:\/\/education.questdiagnostics.com\/faq\/FAQ167(accessed 26 February 2020)."},{"key":"e_1_2_9_44_1","unstructured":"BGI.Nifty. Available online at:https:\/\/www.niftytest.com\/expecting\u2010parents\/intro\u2010to\u2010nifty\/(accessed 24 February 2020)."},{"key":"e_1_2_9_45_1","unstructured":"BiomnisE.Ninalia. Available online at:https:\/\/www.nipt\u2010biomnis.com\/healthcare\u2010provider\/faq\/#\/chapter_1_11(accessed 25 February 2020)."},{"key":"e_1_2_9_46_1","unstructured":"Invitae.Invitae. Available online at:https:\/\/www.invitae.com\/en\/noninvasive\u2010prenatal\u2010screening\/(accessed 23 February 2020)."},{"key":"e_1_2_9_47_1","unstructured":"VCGS.Percept. Available online at:https:\/\/www.vcgs.org.au\/tests\/perceptnipt(accessed 23 February 2020)"},{"key":"e_1_2_9_48_1","unstructured":"Myriad.Myriad Prequel Prenatal Screen. Available online at:https:\/\/myriadwomenshealth.com\/patient\/prequel\u2010prenatal\u2010screen\/(accessed 23 February 2020)."},{"key":"e_1_2_9_49_1","unstructured":"SynLab.NeoBona. Available online at:http:\/\/www.neobona.co.uk\/profesional\u2010sanitario.aspx\/(accessed 23 February 2020)."},{"key":"e_1_2_9_50_1","unstructured":"Progenity.Innatal. Available online at:https:\/\/www.progenity.com\/tests\/innatal#basics(accessed 23 February 2020)."},{"key":"e_1_2_9_51_1","unstructured":"Centogene.CentoNIPT. Available online at:https:\/\/www.centogene.com\/diagnostics\/non\u2010invasive\u2010prenatal\u2010testing.html(accessed 23 February 2020)."}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.13848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.13848","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T06:40:42Z","timestamp":1693982442000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,17]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/aogs.13848"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13848","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,17]]},"assertion":[{"value":"2019-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}