{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:53:32Z","timestamp":1791849212393,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004817","name":"Lund University Medical Faculty Foundation","doi-asserted-by":"publisher","award":["ALF"],"award-info":[{"award-number":["ALF"]}],"id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) has exposed vulnerable populations to an unprecedented global health crisis. The knowledge gained from previous human coronavirus outbreaks suggests that pregnant women and their fetuses are particularly susceptible to poor outcomes. The objective of this study was to summarize the clinical manifestations and maternal and perinatal outcomes of COVID\u201019 during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We searched databases for all case reports and series from 12 February to 4 April 2020. Multiple terms and combinations were used including COVID\u201019, pregnancy, maternal mortality, maternal morbidity, complications, clinical manifestations, neonatal morbidity, intrauterine fetal death, neonatal mortality and SARS\u2010CoV\u20102. Eligibility criteria included peer\u2010reviewed publications written in English or Chinese and quantitative real\u2010time polymerase chain reaction (PCR) or dual fluorescence PCR\u2010confirmed SARS\u2010CoV\u20102 infection. Unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, cases with suspected COVID\u201019 that were not confirmed by a laboratory test, and unreported maternal or perinatal outcomes were excluded. Data on clinical manifestations, maternal and perinatal outcomes including vertical transmission were extracted and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen articles reporting data from 108 pregnancies between 8 December 2019 and 1 April 2020 were included in the current study. Most reports described women presenting in the third trimester with fever (68%) and coughing (34%). Lymphocytopenia (59%) with elevated C\u2010reactive protein (70%) was observed and 91% of the women were delivered by cesarean section. Three maternal intensive care unit admissions were noted but no maternal deaths. One neonatal death and one intrauterine death were also reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the majority of mothers were discharged without any major complications, severe maternal morbidity as a result of COVID\u201019 and perinatal deaths were reported. Vertical transmission of the COVID\u201019 could not be ruled out. Careful monitoring of pregnancies with COVID\u201019 and measures to prevent neonatal infection are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.13867","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T13:18:25Z","timestamp":1586265505000},"page":"823-829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":606,"title":["Maternal and perinatal outcomes with COVID\u201019: A systematic review of 108 pregnancies"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-1578","authenticated-orcid":false,"given":"Mehreen","family":"Zaigham","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6 Department of Obstetrics &amp; Gynecology Lund University and Sk\u00e5ne University Hospital Malm\u00f6\/Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Pediatrics\/Neonatology Lund University Malm\u00f6\/Lund Sweden"},{"name":"Department of Neonatology Sk\u00e5ne University Hospital Malm\u00f6\/Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2018.04.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000182483.24836.66"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(97)80069-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1201\/b18316","volume-title":"Handbook of Obstetric Medicine","author":"Nelson\u2010Piercy C","year":"2015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-017-0070-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001502"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_10_11_1","unstructured":"ThorntonJ.Covid\u201019 in Pregnancy.https:\/\/ripe\u2010tomato.org\/2020\/03\/22\/covid\u201019\u2010in\u2010pregnancy. 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[Pregnant women with new coronavirus infection: clinical characteristics and placental pathological analysis of three cases]","volume":"49","author":"Chen S","year":"2020","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"issue":"18","key":"e_1_2_10_32_1","first-page":"1848","article-title":"Antibodies in infants born to mothers with COVID\u201019 pneumonia","volume":"323","author":"Zeng H","year":"2020","journal-title":"JAMA"},{"issue":"18","key":"e_1_2_10_33_1","first-page":"1846","article-title":"Possible vertical transmission of SARS\u2010CoV\u20102 from an infected mother to her newborn","volume":"323","author":"Dong L","year":"2020","journal-title":"JAMA"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4868"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_36_1","unstructured":"World Health Organization.Novel Coronavirus \u2013 China.2020.https:\/\/www.who.int\/csr\/don\/12\u2010january\u20102020\u2010novel\u2010coronavirus\u2010china\/en\/. 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