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This study evaluated the predictive value of longitudinal salivary uric acid measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Pregnant women (n\u00a0=\u00a0137) from 20\u00a0weeks of gestation were recruited at St Richards Hospital, Chichester, UK, for this prospective cohort study. Weekly samples of salivary uric acid were analyzed until delivery. Information regarding pregnancy and labor were obtained from the patient\u2019s record after delivery. Independent <jats:italic>t<\/jats:italic> tests were used to compare mean levels of salivary uric acid in women with hypertensive complications and adverse fetal outcomes with women with normal pregnancies. Main outcome measures were preeclampsia, pregnancy\u2010induced hypertension, spontaneous preterm delivery and small\u2010for\u2010gestational\u2010age babies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 21\u00a0weeks of gestation until delivery, levels of salivary uric acid increased significantly in women who subsequently developed preeclampsia and pregnancy\u2010induced hypertension compared with women with normal pregnancies (preeclampsia\u2014mean at gestational age 21\u201024, 95% confidence interval [95% CI] [mean <jats:sub>GA21\u201024<\/jats:sub>): 108 [63\u2010185]\u00a0vs 47 (39\u201055)\u00a0\u00b5mol\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005; pregnancy\u2010induced hypertension\u2014mean <jats:sub>GA21\u201024<\/jats:sub>: 118 [54\u2013258]\u00a0vs 47 [39\u201055]\u00a0\u00b5mol\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004). In women who had spontaneous preterm delivery, salivary uric acid levels increased significantly from 29 to 32\u00a0weeks of gestation compared with women with normal pregnancies (mean <jats:sub>GA29\u201032<\/jats:sub>: 112 (57\u2010221)\u00a0vs 59 (50\u201071)\u00a0\u00b5mol\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). In women who had babies small\u2010for\u2010gestational\u2010age &lt;10th percentile and small\u2010for\u2010gestational\u2010age &lt;3rd percentile, differences in salivary uric acid levels were insignificant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated levels of salivary uric acid precede the onset of preeclampsia, pregnancy\u2010induced hypertension and preterm delivery. Salivary uric acid may prove to be an early biomarker of hypertensive complications of pregnancy and spontaneous preterm delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13888","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T01:50:28Z","timestamp":1588211428000},"page":"1339-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Salivary uric acid as a predictive test of preeclampsia, pregnancy\u2010induced hypertension and preterm delivery: A pilot study"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9670-0348","authenticated-orcid":false,"given":"Ida Catharina","family":"P\u00fcschl","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Gynecology and Obstetrics and ReproHealth Consortium Zealand University Hospital Koege Koege Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Bonde","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Herlev\u2010Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel C.","family":"Reading","sequence":"additional","affiliation":[{"name":"Biostatistics Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paddy","family":"Maguire","sequence":"additional","affiliation":[{"name":"Morgan Innovation and Technology Ltd Petersfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Macklon","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics and ReproHealth Consortium Zealand University Hospital Koege Koege Denmark"},{"name":"London Women\u2019s Clinic London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas B.","family":"Van Rijn","sequence":"additional","affiliation":[{"name":"Academic Unit of Human Development and Health University of Southampton Southampton UK"},{"name":"Department of Obstetrics and Gynecology Erasmus MC Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6564"},{"key":"e_1_2_10_3_1","first-page":"63","volume-title":"Make every mother and child count","author":"WHO","year":"2005"},{"key":"e_1_2_10_4_1","unstructured":"MBRRACE\u2010UK Maternal Report 2016[Internet]. 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