{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:18Z","timestamp":1787013858711,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:00:00Z","timestamp":1589673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16411963100"],"award-info":[{"award-number":["16411963100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["134119a4400"],"award-info":[{"award-number":["134119a4400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Preeclampsia affects about 10% of twin pregnancies and significantly increases the risk of adverse pregnancy outcomes. However, screening models for preeclampsia in twin pregnancies remain elusive. The present study aimed to evaluate the performance of a multi\u2010marker first trimester preeclampsia screening model in low\u2010risk twin pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Between 2014 and 2017, we prospectively assessed first trimester biomarkers for preeclampsia in a \u2018low\u2010risk\u2018 twin pregnancy cohort at a single center. Multiple logistic regression was used to determine significant predictors for early preeclampsia (occurring prior to 34\u00a0weeks) and late preeclampsia (occurring after 34\u00a0weeks). The performance of the screening models fitted using the significant predictors was calculated using receiver operating characteristics curves, and internal validation was performed using bootstrapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 769 twin pregnancies were included in the study. Early preeclampsia and late preeclampsia developed in 27 (3.5%) and 59 (7.7%) cases, respectively. Logistic regression analyses showed that maternal age, body mass index, mean artery pressure and placental growth factor were significant predictors for early preeclampsia. Maternal age, body mass index, mean artery pressure and pregnancy\u2010associated plasma protein A were significant for late preeclampsia. Uterine artery pulsatility index was not predictive of either early or late preeclampsia. For the fitted screening model of early and late preeclampsia, the areas under receiver operating characteristics curves were 0.82 (95% confidence interval [CI] 0.76\u20100.88) and 0.66 (95% CI 0.59\u20100.73), which were expected to decrease to 0.77 and 0.60, respectively, based on bootstrapping; the positive predictive values were 10.2% and 12.5%; and the estimated detection rates were 40.7% and 22.0%, respectively, at a false\u2010positive rate of 10%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A multi\u2010marker screening model for preeclampsia in low\u2010risk twin pregnancies, using a modified version of Fetal Medicine Foundation predictors in singletons, does not perform well. Uterine artery pulsatility index is of little value in screening for preeclampsia in low\u2010risk twin pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.13890","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T01:59:46Z","timestamp":1588298386000},"page":"1346-1353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Screening for preeclampsia in low\u2010risk twin pregnancies at early gestation"],"prefix":"10.1111","volume":"99","author":[{"given":"Jianping","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Center Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Center Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai China"},{"name":"Department of Reproductive Medicine Affiliated Shenzhen Maternity &amp; Child Healthcare Hospital Southern Medical University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Center Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai China"},{"name":"Shanghai Putuo District Maternity and Infant Hospital Corporation Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Center Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Center Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and gynecology Mount Sinai Hospital and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-0383","authenticated-orcid":false,"given":"Luming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Center Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai 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