{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:10:19Z","timestamp":1777392619944,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Transcervical resection of the endometrium (TCRE) is a first\u2010line surgical treatment of abnormal uterine bleeding. However, many women experience unsuccessful results, causing hysterectomy in up 17% of cases. The aim of this study was to describe the odds of hysterectomy in women with abnormal uterine bleeding, treated with TCRE and levonorgestrel intrauterine contraceptive device (TCRE\u00a0+\u00a0LNG\u2010IUCD) or TCRE alone. The secondary aim was to analyze the rate of amenorrhea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Designed as a retrospective cohort study, and conducted at Odense University Hospital, Denmark, the study included women with abnormal uterine bleeding, who underwent TCRE from January 2013 to December 2015. The decision of treatment with respect to LNG\u2010IUCD was at the woman's discretion. Data were collected from medical records and a self\u2010reported retrospective bleeding\u2010pattern questionnaire. A multivariate regression model was used, enabling adjustment for potential and identified confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 432 women, 276 (62%) consented to inclusion and of these, 16 (4%) were excluded. In total 88 (34%) received combined treatment and 172 (66%) received TCRE alone. Ten women (11%) treated with TCRE\u00a0+\u00a0LNG\u2010IUCD underwent hysterectomy, compared with 27 (16%) treated with TCRE alone (OR\u00a0=\u00a00.69, 95% CI 0.28\u20101.56; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.34). Multivariate analysis disclosed a significant effect of TCRE\u00a0+\u00a0LNG\u2010IUCD (OR\u00a0=\u00a00.35, 95% CI 0.13\u20100.97; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) on hysterectomy. The presence of fibromas was shown to increase the odds of treatment failure, resulting in hysterectomy (OR 2.69, 95% CI 1.15\u20106.31; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Furthermore, the incidence of amenorrhea was 59% in the TCRE\u00a0+\u00a0LNG\u2010IUCD group and 36% in the TCRE alone group (OR\u00a0=\u00a02.56, 95% CI 1.46\u20104.49; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study showed significantly lower odds of hysterectomy in the TCRE\u00a0+\u00a0LNG\u2010IUCD group when adjusted for confounders. Combination treatment improves the bleeding patterns significantly compared with monotherapy with TCRE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13949","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T19:44:45Z","timestamp":1593632685000},"page":"1554-1560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combined transcervical endometrial resection and levonorgestrel device treatment compared to transcervical endometrial resection for abnormal uterine bleed"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-860X","authenticated-orcid":false,"given":"Pernille","family":"Darre Haahr","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia\u2010Kim B.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Grunnet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Rudnicki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.92"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.02.026"},{"key":"e_1_2_10_4_1","first-page":"359","article-title":"An epidemiological survey of symptoms of menstrual loss in the community","volume":"54","author":"Shapley M","year":"2004","journal-title":"Br J Gen Pract"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00168.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02094-X"},{"key":"e_1_2_10_7_1","first-page":"CD003855","article-title":"Surgery versus medical therapy for heavy menstrual bleeding","author":"Marjoribanks J","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_1","first-page":"CD001501","article-title":"Endometrial resection and ablation techniques for heavy menstrual bleeding","volume":"8","author":"Lethaby A","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2015.06.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12259"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6960.979"},{"key":"e_1_2_10_12_1","unstructured":"Dansk Hysterektomi og Hysteroskopi Databases National Aarsraport 2017\/18[The Danish Hysterectomy and Hysteroscopy Database National Yearly Report 2017\/18] In Danish. 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