{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:10:47Z","timestamp":1787508647735,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Newborn infants with transposition of the great arteries (d\u2010TGA) need immediate care for an optimal outcome. This study comprised a nationwide 11\u2010year population\u2010based cohort of d\u2010TGA infants, and assessed whether the implementation of a nationwide systematic fetal screening program, or other perinatal, or perioperative factors, are associated with mortality or an increased need for hospital care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>The national cohort consisted of all live\u2010born infants with simple d\u2010TGA (TGA\u00a0\u00b1\u00a0small ventricular septal defect, n\u00a0=\u00a0127) born in Finland during 2004\u20102014. Data were collected from six national registries. Prenatal diagnosis and perinatal and perioperative factors associated with mortality and length of hospitalization were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Preoperative mortality was 7.9%, and the total mortality was 8.7%. The prenatal detection rate increased after introducing systematic fetal anomaly screening from 5.0% to 37.7% during the study period (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001), but the total mortality rate remained unchanged. All prenatally diagnosed infants (n\u00a0=\u00a027) survived. Lower gestational age (odds ratio 0.68,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.012) and higher maternal age at birth (odds ratio 1.16,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.036) were associated with increased mortality in multivariable analysis. Older infant age at time of operation (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002), longer aortic clamp time (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), and higher maternal body mass index (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.027) were associated with longer initial hospital stay. An extended need for hospital care during the first year of life was multi\u2010factorial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our cohort, none of the prenatally diagnosed d\u2010TGA infants died. As a result of the limited prenatal detection rates, however, the sample size was insufficient to reach statistical significance. The d\u2010TGA infants born with lower gestational age and to older mothers had increased mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.13953","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T16:25:03Z","timestamp":1594225503000},"page":"1728-1735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Perinatal and perioperative factors associated with mortality and an increased need for hospital care in infants with transposition of the great arteries: A nationwide 11\u2010year population\u2010based cohort"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5960-6088","authenticated-orcid":false,"given":"Johanna","family":"Hautala","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Women's Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"Information Services Department Finnish Institute for Health and Welfare Helsinki Finland"},{"name":"Department of Neurobiology, Care Sciences and Society Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annukka","family":"Ritvanen","sequence":"additional","affiliation":[{"name":"Retired from the Register of Congenital Malformations Finnish Institute for Health and Welfare Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmi","family":"Helle","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Children's Hospital Helsinki University Hospital and University of Helsinki Helsinki 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