{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:55:08Z","timestamp":1792634108604,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Corpus callosum agenesis (ACC) is frequently diagnosed during fetal life; its prognosis depends also on additional anomalies. The additional value of fetal magnetic resonance imaging (MRI) in fetuses with \u201cisolated\u201d complete (cACC) and partial (pACC) agenesis of the corpus callosum on ultrasound is still debated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We performed a systematic literature review and meta\u2010analysis including fetuses with a prenatal diagnosis of cACC and pACC without associated structural anomalies on ultrasound, undergoing fetal MRI. The primary outcome was the rate of additional anomalies detected at fetal MRI. Further analyses assessed the effect of type of ultrasound assessment (neurosonography vs standard axial assessment), gestational age at fetal MRI and rate of postnatally detected brain anomalies. Random\u2010effect meta\u2010analyses of proportions were used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen studies <jats:bold>(<\/jats:bold>798 fetuses) were included. In cases with isolated cACC, 10.9% (95% CI 4.1\u201020.6) and 4.3% (95% CI 1.4\u20108.8) additional anomalies were detected by fetal MRI and postnatally, respectively. Stratifying according to the type of ultrasound assessment, the rate of associated anomalies detected only on fetal MRI was 5.7% (95% CI 0.5\u201016.0) with dedicated neurosonography and 18.5% (95% CI 7.8\u201032.4) with a standard axial assessment. In fetuses with isolated pACC, 13.4% (95% CI 4.0\u201027.0) and 16.2% (95% CI 5.9\u201030.3) additional anomalies were detected by fetal MRI or postnatally, respectively. Stratifying according to the type of ultrasound assessment, the rate of associated anomalies detected only on fetal MRI was 11.4% (95% CI 2.7\u201025.0) when dedicated neurosonography was performed. Cortical and posterior fossa anomalies represented the most common anomalies missed at ultrasound with both cACC and pACC. Due to the very small number of included cases, stratification according to early (&lt;24\u00a0weeks of gestation) and late (&gt;24\u00a0weeks) fetal MRI could not be done for either cACC or pACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rate of associated anomalies detected exclusively at fetal MRI in isolated ACC undergoing neurosonography is lower than previously reported. Cortical and posterior fossa anomalies are among the most common anomalies detected exclusively at MRI, thus confirming the crucial role of fetal MRI in determining the prognosis of these fetuses. However, some anomalies still go undetected prenatally and this should be stressed during parental counseling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13958","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T20:55:51Z","timestamp":1594500951000},"page":"7-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Role of prenatal magnetic resonance imaging in fetuses with isolated agenesis of corpus callosum in the era of fetal neurosonography: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-0576","authenticated-orcid":false,"given":"Filomena Giulia","family":"Sileo","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Saint George\u2019s Hospital London UK"},{"name":"Prenatal Medicine Unit, Obstetrics and Gynecology Unit Department of Medical and Surgical Sciences for Mother, Child and Adult University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-3393","authenticated-orcid":false,"given":"Daniele","family":"Di Mascio","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Division of Maternal and Fetal Medicine Ospedale Cristo Re University of Rome Tor Vergata Rome Italy"},{"name":"Department of Obstetrics and Gynecology The First I.M. Sechenov Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Caulo","sequence":"additional","affiliation":[{"name":"ITAB Institute of Advanced Biomedical Technologies University \u201cG. d\u2019Annunzio\u201d Chieti Italy"},{"name":"Department of Neuroscience, Imaging and Clinical Sciences University \u201cG. d\u2019Annunzio\u201d SS Annunziata Hospital Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Manganaro","sequence":"additional","affiliation":[{"name":"Department of Radiology Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Bertucci","sequence":"additional","affiliation":[{"name":"Prenatal Medicine Unit, Obstetrics and Gynecology Unit Department of Medical and Surgical Sciences for Mother, Child and Adult University of Modena and Reggio Emilia Modena 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