{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:42:16Z","timestamp":1792651336719,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Endometriosis is a very common disease that affects up to 10% of the female population. The use of indocyanine green (ICG) dye has been proposed to allow the proper localization of endometriotic lesions during surgery. Our purpose is to offer an overview of near\u2010infrared (NIR)\u2010ICG in the surgical treatment of superficial peritoneal endometriosis and deep infiltrating endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Electronic databases were searched, including MEDLINE, Embase, Web of Science, Scopus, ClinicalTrial.gov, OVID and Cochrane Library. The studies were identified with the use of a mesh combination of the following keywords: \u201cindocyanine green\u201d, \u201cendometriosis\u201d, \u201cdeep endometriosis\u201d, \u201crobotic surgery\u201d, \u201claparoscopy\u201d, \u201cureter\u201d, \u201crectosigmoid\u201d from 2000 to May 2020. All articles describing the use of ICG applied to endometriosis surgery were considered for review. Only original papers that reported specific experience data on the topic were included. Moreover, video\u2010articles were included in the analysis. Quality and risk of bias were evaluated by two authors, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three studies were reviewed and reviews or comment articles not reporting original data and original articles lacking specific data on the application of ICG in patients affected by endometriosis were excluded. The quality of the 17 studies included was assessed. Eight studies suggested the usefulness of NIR\u2010ICG as a tool in the detection of endometriosis during surgery, and one randomized controlled trial and one prospective study did not confirm the advantage of its use. Eight studies found that NIR\u2010ICG was useful for the evaluation of vascularization in intestinal anastomoses and ureterolysis after surgery for deep infiltrating endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NIR\u2010ICG appears useful in the evaluation of vascularization in intestinal anastomoses after segmental resection, confirming its role even after ureterolysis for parametrial deep infiltrating endometriosis. However, its usefulness as a tool in the detection of endometriosis during surgery is inconsistent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13971","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T12:04:29Z","timestamp":1596888269000},"page":"189-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Indocyanine green in the surgical management of endometriosis: A systematic review"],"prefix":"10.1111","volume":"100","author":[{"given":"Manuel M.","family":"Ianieri","sequence":"first","affiliation":[{"name":"Division of Gynecological Oncology Department for the Protection of Women\u2019s and Children\u2019s Health and Public Health Fondazione Policlinico Universitario A. Gemelli IRCCS L.go A. 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Gemelli Rome Italy"},{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry School of Medicine University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Campolo","sequence":"additional","affiliation":[{"name":"University Hospital for Gynecology Pius Hospital Oldenburg Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cosentino","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Gemelli Molise Hospital Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Catena","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology Department for the Protection of Women\u2019s and Children\u2019s Health and Public Health Fondazione Policlinico Universitario A. Gemelli IRCCS L.go A. 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