{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:42:17Z","timestamp":1792460537685,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Increased soluble fms\u2010like tyrosine kinase to placental growth factor ratio (sFlt\u20101\/PlGF) has been demonstrated in early\u2010onset fetal growth restriction (FGR) and small for gestational age (SGA). sFlt\u20101\/PlGF cut\u2010offs have been described to assess preeclampsia severity; however, sFlt\u20101\/PlGF values present in early\u2010onset SGA and different FGR severity stages remain unknown. Hence, the objective of this study was to describe and compare the sFlt\u20101\/PlGF values and pregnancy outcomes among early\u2010onset SGA\/FGR stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This is a prospective case\u2010control study conducted at Vall d\u2019Hebron University Hospital. Singleton pregnancies with estimated fetal weight &lt;10th centile and a control group of uncomplicated pregnancies between 20<jats:sup>+0<\/jats:sup> and 31<jats:sup>+6<\/jats:sup>\u00a0weeks of gestation were enrolled. Study women were classified at diagnosis into different stages, according to estimated fetal weight centile and Doppler ultrasound. sFlt\u20101\/PlGF serum concentrations were measured at diagnosis and, together with pregnancy outcomes, were compared among FGR severity stages, SGA, and controls. Finally, correlations between sFlt\u20101\/PlGF values and time to delivery, gestational age at delivery, days of neonatal admission, and birthweight <jats:italic>z<\/jats:italic>\u2010scores were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 207 women enrolled, 32 (15.4%) had uncomplicated pregnancies, 49 (23.7%) pregnancies showed SGA, and 126 (60.9%) involved FGR (92 being stage I, 17 stage II, and 17 stage III). SGA and controls had similar median sFlt\u20101\/PlGF values (25.7 vs 27.1, <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05) and pregnancy outcomes. However, all FGR stages had significantly poorer outcomes and greater sFlt\u20101\/PlGF values than those of SGA and controls. Furthermore, median values differed significantly among all FGR severity stages (9.76 for stage I; 284.3 for stage II, and 625.02 for stage III, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) increasing with FGR severity as well as the frequency of adverse pregnancy outcomes. Additionally, a significant correlation was found between greater sFlt\u20101\/PlGF ratio values and gestational age at delivery, time from diagnosis to delivery, birthweight <jats:italic>z<\/jats:italic>\u2010scores, and time in neonatal intensive care unit (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.637, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.576, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.161, and <jats:italic>r\u00a0<\/jats:italic>=\u00a0.311, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Values of sFlt\u20101\/PlGF at diagnosis permit early\u2010onset FGR\/SGA severity classification with good correlation with Doppler ultrasound findings and the occurrence of adverse outcomes. Thus, sFlt\u20101\/PlGF could aid in early\u2010onset FGR\/SGA severity classification and clinical management when Doppler assessment is not feasible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13978","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T08:51:22Z","timestamp":1598691082000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Soluble fms\u2010like tyrosine kinase to placental growth factor ratio in different stages of early\u2010onset fetal growth restriction and small for gestational age"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-1626","authenticated-orcid":false,"given":"Pablo","family":"Garcia\u2010Manau","sequence":"first","affiliation":[{"name":"Maternal Fetal Medicine Unit Department of Obstetrics Hospital Universitari Valld\u2019Hebron Universitat Aut\u00f2noma de Barcelona Barcelona 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