{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:34:49Z","timestamp":1781130889616,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","award":["15\u2010243"],"award-info":[{"award-number":["15\u2010243"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite smoking being a well\u2010established risk factor for adverse pregnancy and neonatal outcomes, a substantial proportion of women of reproductive age smoke. Previously, meta\u2010analyses have indicated a significantly negative impact of female smoking on outcomes of assisted reproduction, yet most of the included studies have several, essential methodological limitations. We aimed to investigate whether female cigarette smoking may affect the chance of achieving a clinical pregnancy and live birth among women and couples receiving medically assisted reproduction treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A cohort study with longitudinally and repeatedly collected exposure information from 1 January 2010 to 31 August 2015, including data on 1708 women and potential partners initiating either intrauterine insemination, in vitro fertilization (IVF)\/intracytoplasmic sperm injection (ICSI) or frozen embryo transfer treatment cycles at the public Fertility Clinic, Aarhus University Hospital, Denmark. Smoking was assessed from self\u2010reported questionnaires completed before treatment. Outcomes were a clinical pregnancy and a live birth. Information on these was obtained from the Danish national health registries, allowing complete follow\u2010up. To evaluate associations between female occasional\/daily cigarette smoking and successful medically assisted reproduction treatments, a modified Poisson regression with robust standard errors was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Female occasional\/daily cigarette smoking was not associated with the chance of achieving a clinical pregnancy or a live birth in all intrauterine insemination or IVF\/ICSI treatment cycles. When compared with nonsmokers, the adjusted relative risk for obtaining a live birth for those reporting smoking was 1.22 (0.70\u20102.12) among women initiating 1456 intrauterine insemination treatment cycles. Among women initiating 2788 IVF\/ICSI treatment cycles, those reporting occasional\/daily smoking had a relative risk for obtaining a live birth of 1.15 (0.82\u20101.60) when compared with nonsmokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Occasionally\/daily cigarette smoking women had similar chance of achieving a clinical pregnancy or a live birth as the nonsmokers when receiving medically assisted reproduction treatments. However, tobacco use before and during pregnancy remains a major cause of reduced fertility as well as maternal, fetal, and infant morbidity and mortality, and should strongly be discouraged.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13979","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T15:44:35Z","timestamp":1598888675000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Female cigarette smoking and successful fertility treatment: A Danish cohort study"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-5712","authenticated-orcid":false,"given":"Julie","family":"Lyngs\u00f8","sequence":"first","affiliation":[{"name":"Research Unit for Epidemiology Department of Public Health Aarhus University Aarhus Denmark"},{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-106X","authenticated-orcid":false,"given":"Ulrik S.","family":"Kesmodel","sequence":"additional","affiliation":[{"name":"Fertility Unit Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Bay","sequence":"additional","affiliation":[{"name":"The Fertility Clinic Regional Hospital Horsens Horsens Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Ingerslev","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"},{"name":"Fertility Unit Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotta H.","family":"Pisinger","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia H.","family":"Ramlau\u2010Hansen","sequence":"additional","affiliation":[{"name":"Research Unit for Epidemiology Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"107","article-title":"The 2004 United States Surgeon General's Report: The Health Consequences of Smoking","volume":"15","author":"Surgeon General","year":"2004","journal-title":"N S W Public Health Bull"},{"key":"e_1_2_10_3_1","volume-title":"The Health Consequences of Smoking\u201450 Years of Progress: A Report of the Surgeon General","author":"Surgeon General","year":"2014"},{"key":"e_1_2_10_4_1","first-page":"1108","article-title":"Current cigarette smoking among adults\u2014United States, 2005\u20132013","volume":"63","author":"Jamal A","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_10_5_1","volume-title":"Danskernes rygevaner, 1994 to 2017 [Smoking habits of the Danes, in Danish]","author":"Danish Health Authority","year":"2018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey372"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq033"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.11.037"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des070"},{"key":"e_1_2_10_10_1","first-page":"390","article-title":"Infertility and assisted reproduction in Denmark, Epidemiology and psychosocial consequences","volume":"53","author":"Schmidt L","year":"2006","journal-title":"Dan Med Bull"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex264"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.06.016"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_10_14_1","first-page":"357","article-title":"The Danish in vitro fertilisation (IVF) register","volume":"46","author":"Andersen AN","year":"1999","journal-title":"Dan Med Bull"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0356-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394715"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13293"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-009-9330-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn046"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2018.08.004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31821b5351"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2018.7293"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq381"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-017-0105-0"},{"key":"e_1_2_10_28_1","volume-title":"Danskernes Sundhed\u2014Den Nationale Sundhedsprofil 2017 [National Health Survey 2017, in Danish]","author":"Rosendahl Jensen HDM","year":"2018"},{"key":"e_1_2_10_29_1","first-page":"63","article-title":"Ascorbic acid and infertility treatment","volume":"11","author":"Crha I","year":"2003","journal-title":"Cent Eur J Public Health"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu239"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.01.167"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntt127"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.13979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T03:30:26Z","timestamp":1693539026000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/aogs.13979"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13979","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]},"assertion":[{"value":"2020-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}