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However, studies concerning fetal central hemodynamics have revealed conflicting results. We hypothesized that in pregnancies complicated by maternal type 1 diabetes, fetal cardiovascular and placental hemodynamics are comparable to the control fetuses at near\u2010term gestation. In addition, we investigated the relation between newborn serum biomarkers of cardiac function and fetal cardiovascular and placental hemodynamics. Furthermore, we studied whether maternal diabetes is associated with placental inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this prospective case\u2010control study, fetal central and peripheral hemodynamics were assessed by ultrasonography in 33 women with type 1 diabetes and in 67 controls with singleton pregnancies between 34<jats:sup>+2<\/jats:sup> and 40<jats:sup>+2<\/jats:sup> gestational weeks. Newborn umbilical cord serum was collected to analyze cardiac natriuretic peptides (atrial and B\u2010type natriuretic peptides) and troponin T concentrations. Placental tissue samples were obtained for cytokine analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetal ventricular wall thicknesses were greater and weight\u2010adjusted stroke volumes and cardiac outputs were lower in the type 1 diabetes group than in the control group. Pulsatility in the aortic isthmus and inferior vena cava blood flow velocity waveforms was greater in the type 1 diabetes group fetuses than in the controls. A positive correlation was found between branch pulmonary artery and aortic isthmus pulsatility index values. Umbilical artery pulsatility indices were comparable between the groups. Umbilical cord serum natriuretic peptide and troponin T concentrations were elevated in the type 1 diabetes fetuses. These cardiac biomarkers correlated significantly with cardiovascular hemodynamics. Placental cytokine levels were not different between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In maternal type 1 diabetes pregnancies, fetal cardiovascular hemodynamics is impaired. Maternal type 1 diabetes does not seem to alter placental vascular impedance or induce placental inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13987","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T05:31:29Z","timestamp":1599111089000},"page":"263-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fetal cardiovascular hemodynamics in type 1 diabetic pregnancies at near\u2010term gestation"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-2411","authenticated-orcid":false,"given":"Lara","family":"Lehtoranta","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Turku, and Turku University Hospital Turku Finland"},{"name":"Institute of Biomedicine Department of Physiology University of Oulu Oulu Finland"},{"name":"The Research Center of Applied and Preventive Cardiovascular Medicine (CAPC) University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervi","family":"Haapsamo","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine Department of Physiology University of Oulu Oulu Finland"},{"name":"Satakunta Central Hospital Pori Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Vuolteenaho","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine Department of Physiology University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pertti","family":"Palo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Turku, and Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeva","family":"Ekholm","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Turku, and Turku University 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