{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:45:31Z","timestamp":1774680331633,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>High\u2010dose progestins are used as an effective therapy for painful symptoms of endometriosis but their impact on sexual function has been poorly studied. The study aims to assess the impact of high\u2010dose progestin on sexual function among women treated for endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this bicenter prospective observational study, women with endometriosis who received medical or surgical treatment for endometriosis and who were sexually active were included. They completed the Sexual Activity Questionnaire (SAQ, a validated tool) before (T0) and 12\u00a0months after (T1) endometriosis treatment. We classified patients into two groups according to whether they were using high\u2010dose progestins at T1: a high\u2010dose progestin group and a control group. The main outcome was sexual function measured by the SAQ score (from 0 to 30) at T1. The secondary outcomes were each individual SAQ item, the dyspareunia 100\u2010mm visual analog scale (VAS) and the quality of life assessed with EuroQoL Group 5D Index (EQ\u20105D) at T1. We also assessed the change in dyspareunia VAS and quality of life between T0 and T1. The Ethics Committee of Ile\u2010de\u2010France (Act 2004\u2010806, 9 August 2004) approved the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 214 women included, 25 (12%) were exposed to high\u2010dose progestins at T1. The SAQ score of women exposed to high\u2010dose progestins was significantly lower compared with the control group, with or without adjustment for covariates (15.5\u00a0\u00b1\u00a06.3 vs 18.3\u00a0\u00b1\u00a06.2, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03, adjusted effect size \u22120.44 [95% CI \u22120.86 to \u22120.02], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). High\u2010dose progestin intake at T1 was associated with a lower subscore on two SAQ items: pleasure (1.8\u00a0\u00b1\u00a00.8 vs 2.2\u00a0\u00b1\u00a00.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), and satisfaction with frequency of intercourse (1.2\u00a0\u00b1\u00a01.2 vs 1.8\u00a0\u00b1\u00a01.1, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). In the overall population, dyspareunia VAS and quality of life assessed by EQ\u20105D improved between T0 and T1 (45\u00a0\u00b1\u00a029 at T0 vs 28\u00a0\u00b1\u00a029 at T1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; 0.78\u00a0\u00b1\u00a00.14 at T0 vs 0.86\u00a0\u00b1\u00a00.14 at T1, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, respectively). At T1, the groups did not differ significantly for dyspareunia VAS (effect size 0.36 [95% CI \u22120.06 to 0.78], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.10) and quality of life (EQ\u20105D, effect size 0.02 [95% CI \u22120.40 to 0.44], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this observational study, high\u2010dose progestins impair the sexual function of women treated for endometriosis even though they improved dyspareunia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14014","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T13:38:07Z","timestamp":1601818687000},"page":"850-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Do high\u2010dose progestins impair sexual function in women treated for endometriosis? A prospective observational longitudinal study"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-235X","authenticated-orcid":false,"given":"Anne","family":"Oppenheimer","sequence":"first","affiliation":[{"name":"EA 7285 Research Unit \u2018Risk and Safety in Clinical Medicine for Women and Perinatal Health\u2019 Versailles\u2010Saint\u2010Quentin University (UVSQ) Montigny\u2010le\u2010Bretonneux France"},{"name":"Department of Reproductive Medicine and Fertility Preservation H\u00f4pital universitaire Antoine B\u00e9cl\u00e8re Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Verdun","sequence":"additional","affiliation":[{"name":"Biostatistics Department\u2010Delegations for Clinical Research and Innovation Lille Catholic Hospitals Lille Catholic University Lille 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