{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:15Z","timestamp":1787067855261,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Since 2012, cervical cancer screening has been conducted with a primary high\u2010risk human papillomavirus (hrHPV) test and conventional cytology triage in the city of Tampere, Finland. The women who were screened with the hrHPV test in 2012 were invited to participate in the second screening round in 2017. The aim of the present report was to compare the number of colposcopy referrals and the number of histological high\u2010grade squamous intraepithelial lesion (HSIL)+ (cervical intraepithelial neoplasia [CIN2+]) lesions between the first and second screening rounds of women of a specific age group who were screened twice with the hrHPV test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>The primary hrHPV test used was the RealTime hrHPV PCR assay by Abbott. Women with a positive hrHPV test and cytology triage equal to or worse than low\u2010grade squamous intraepithelial lesion or atypical glandular cells, favor neoplasia, were directly referred to colposcopy, whereas hrHPV\u2010positive women with a negative or equivocal cytology triage were re\u2010screened after approximately 12\u201016\u00a0months. hrHPV\u2010negative women were scheduled for re\u2010screening after 5\u00a0years. The present report focuses on the cohort of women who were screened twice with the hrHPV test, who were 35\u201055\u00a0years old in 2012, and 40\u201060\u00a0years old in 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 8076 women were invited for HPV screening in 2012 and 8331 women were invited for the second round 5\u00a0years later, with attendance rates of 70% and 71%, respectively. Of the women who were screened in 2012, 4571 (69%) belonged to the 35\u2010 to 55\u2010year age cohort. In 2017, 4807 (73%) of the women aged 40\u201060\u00a0years participated in the screening. In this cohort, 185 (4.0%) colposcopies were performed in the first screening round, compared with 139 (2.9%) in the second round, and the colposcopy rate was 29% smaller in the second round (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.002). The number of histological HSIL+ cases was 38 (0.8%) during the first screening round and 29 (0.6%) during the second round (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.220).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the setting of routine organized cervical cancer screening, the initially high colposcopy rate associated with primary HPV screening seems to level off at the second screening round in women who were screened twice with an hrHPV test.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14021","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T01:30:52Z","timestamp":1602293452000},"page":"403-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Primary HPV screening for cervical cancer: Results after two screening rounds in a regional screening program in Finland"],"prefix":"10.1111","volume":"100","author":[{"given":"Olga","family":"Veijalainen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology P\u00e4ij\u00e4t\u2010H\u00e4meen Central Hospital Lahti Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Kares","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kotaniemi\u2010Talonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tampere University Hospital, and Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Kujala","sequence":"additional","affiliation":[{"name":"Department of Pathology 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