{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:05:12Z","timestamp":1790031912674,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Fetal growth restriction is associated with adverse perinatal outcome and the clinical management of these pregnancies is a challenge. The aim of this study was to investigate the potential of cerebroplacental ratio (CPR) to predict adverse perinatal outcome in high\u2010risk pregnancies in the third trimester. Another aim was to study whether the CPR has better predictive value than its components, middle cerebral artery (MCA) pulsatility index (PI) and umbilical artery (UA) PI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      The study was a retrospective cohort study including 1573 singleton high\u2010risk pregnancies with Doppler examinations performed at 32\n                      <jats:sup>+0<\/jats:sup>\n                      to 40\n                      <jats:sup>+6<\/jats:sup>\n                      gestational weeks at Lund University Hospital and the University Hospital of Malm\u00f6 between 29 December 1994 and 31 December 2017. Receiver operating characteristics (ROC) curves were used to investigate the predictive value of the gestational age\u2010specific\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores for CPR, UA PI and MCA PI, respectively, for the primary outcome \u201cperinatal asphyxia\/mortality\u201d and the secondary outcomes \u201cbirthweight small for gestational age (SGA)\u201d and two composite outcomes: \u201cappropriate for gestational age\/large for gestational age liveborn infants with neonatal morbidity\u201d and \u201cSGA liveborn infants with neonatal morbidity.\u201d\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The performance in predicting perinatal asphyxia\/mortality was poor for all three variables and did not differ significantly. The ROC area under curve (AUC) was 0.56, 0.55 and 0.53 for CPR, UA PI and MCA PI\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores, respectively. The ROC AUC for CPR\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores to predict SGA was 0.73, significantly higher than that for either UA PI or MCA PI (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The ability of CPR and the MCA PI to predict appropriate for gestational age\/large for gestational age infant morbidity and SGA infant morbidity was similar and significantly better than UA PI (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the present study, none of the three Doppler measures proved to be useful in predicting perinatal asphyxia and mortality. CPR and MCA PI were equally good in predicting neonatal morbidity, especially in SGA pregnancies, and both were significantly better predictors than the UA PI. CPR had a high predictive value for SGA at birth, better than that of its two components, UA PI and MCA PI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14031","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T05:10:34Z","timestamp":1603170634000},"page":"497-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cerebroplacental ratio as predictor of adverse perinatal outcome in the third trimester"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-6890","authenticated-orcid":false,"given":"Anna","family":"Bonnevier","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Department of Obstetrics and Gynecology Ystad Hospital Ystad 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