{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:28:00Z","timestamp":1774686480191,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF16OC0018772"],"award-info":[{"award-number":["NNF16OC0018772"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNFSA170030576"],"award-info":[{"award-number":["NNFSA170030576"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In Denmark, non\u2010invasive prenatal testing (NIPT) has been used since 2013. We aimed to evaluate the early clinical use of NIPT in Danish public and private healthcare settings before NIPT became an integrated part of the national guidelines on prenatal screening and diagnosis in 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>NIPT data were collected between March 2013 and June 2017 from national public registries and private providers. Results from follow\u2010up samples (chorionic villi, amniotic fluid, postnatal blood or fetal tissue) were included from The Danish Cytogenetics Central Registry and indications and outcome from The Danish Fetal Medicine Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3936 NIPT results were included in the study from public hospitals (n\u00a0=\u00a03463, 88.0%) and private clinics (n\u00a0=\u00a0473, 12.0%). The total number of prenatal tests was 19\u00a0713 during the study period: 20% were NIPT analyses (n\u00a0=\u00a03936) and 80% invasive procedures (n\u00a0=\u00a015\u00a0777). Twenty\u2010five percent of NIPTs in the private clinics were performed before gestational week 11<jats:sup>+0<\/jats:sup>, whereas NIPT in public settings was used only after combined first trimester screening (<jats:italic>P<\/jats:italic>\u00a0&lt; .001). Regardless of indication, the national public sensitivity was 96.9% (95% CI 82.0%\u201099.8%) for trisomy 21, 100% (95% CI 46.3%\u2010100%) for trisomy 18, 100% (95% CI 5.5%\u2010100%) for trisomy 13, and 87.0% (95% CI 74.5%\u201092.4%) for any fetal chromosomal aberration. Forty\u2010seven true\u2010positive NIPT results included cases of common aneuplodies (trisomy 21, n\u00a0=\u00a031; trisomy 18, n\u00a0=\u00a05; and trisomy 13, n\u00a0=\u00a01), sex chromosomal aberrations (n\u00a0=\u00a07) and atypical chromosomal aberrations (n\u00a0=\u00a03). One false\u2010negative NIPT result occurred (trisomy 21). Of 47 cases, 21 (45%) cases with a true\u2010positive NIPT result resulted in live births by choice; 11 of these children had Down and 4 had Edwards syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The total number of NIPT analyses was low compared with the number of invasive procedures in the implementation period. In contrast to the generally high termination rate after a positive result following invasive testing in Denmark, a high proportion of true\u2010positive NIPT results from the public setting resulted in live births. NIPT may be an important risk\u2010free alternative to invasive testing for a minority of women in the public setting who wish to use prenatal genetic testing for information only and not for reproductive decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14052","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T08:55:25Z","timestamp":1606208125000},"page":"884-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["National data on the early clinical use of non\u2010invasive prenatal testing in public and private healthcare in Denmark 2013\u20132017"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5480-220X","authenticated-orcid":false,"given":"Ida C. B.","family":"Lund","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark"},{"name":"Center for Fetal Diagnostics Aarhus University Hospital\/Aarhus University Aarhus Denmark"},{"name":"Department of Biomedicine Health, Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-4082","authenticated-orcid":false,"given":"Olav B.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Center for Fetal Medicine Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1264-1940","authenticated-orcid":false,"given":"Naja H.","family":"Becher","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark"},{"name":"Center for Fetal Diagnostics Aarhus University Hospital\/Aarhus University Aarhus Denmark"},{"name":"Department of Biomedicine Health, Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte L.","family":"Lildballe","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark"},{"name":"Center for Fetal Diagnostics Aarhus University Hospital\/Aarhus University Aarhus Denmark"},{"name":"Department of Biomedicine Health, Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn S.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Obstetrics and Gynecology and Hvidovre Hospital\u2019s NIPT Center Fetal Medicine Unit Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Ambye","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Hvidovre Hospital\u2019s NIPT Center Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Skibsted","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Roskilde Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann N.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Fagerberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Brasch\u2010Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Tabor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Center for Fetal Medicine Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helle J.","family":"Zingenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Copenhagen University Hospital Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Copenhagen University Hospital Hiller\u00f8d Hospital Hiller\u00f8d Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitte J.","family":"Almind","sequence":"additional","affiliation":[{"name":"Copenhagen Fertility Center Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else Marie","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark"},{"name":"Center for Fetal Diagnostics Aarhus University Hospital\/Aarhus University Aarhus Denmark"},{"name":"Department of Biomedicine Health, Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-0393","authenticated-orcid":false,"given":"Ida","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark"},{"name":"Center for Fetal Diagnostics Aarhus University Hospital\/Aarhus University Aarhus Denmark"},{"name":"Department of Biomedicine Health, Aarhus University Aarhus 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Available online at:https:\/\/www.sst.dk\/da\/udgivelser\/2017\/\/\u2010\/media\/Udgivelser\/2017\/Fosterdiagnostik\/Retningslinjer\u2010for\u2010fosterdiagnostik.ashx(accessed 21 October 2020)."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15820"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13270"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19035"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18979"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23232"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5698"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13273"},{"key":"e_1_2_10_17_1","first-page":"A5359","article-title":"The rate of invasive testing for trisomy 21 is reduced after implementation of NIPT","volume":"64","author":"Bjerregaard L","year":"2017","journal-title":"Danish Med J"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4819"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2547"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12380"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17283"},{"key":"e_1_2_10_22_1","first-page":"A5486","article-title":"Preferences for prenatal testing among pregnant women, partners and health professionals","volume":"65","author":"Lund ICB","year":"2018","journal-title":"Dan Med J"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13297"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-018-0188-1"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17533"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3426"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.14052","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:01:49Z","timestamp":1693551709000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,24]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/aogs.14052"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14052","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,24]]},"assertion":[{"value":"2020-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}