{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:45:35Z","timestamp":1790318735345,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:00:00Z","timestamp":1608854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010727","name":"Axel Muusfeldts Fond","doi-asserted-by":"publisher","award":["2017\u2010831"],"award-info":[{"award-number":["2017\u2010831"]}],"id":[{"id":"10.13039\/100010727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Placental transverse relaxation time (T2) assessed by MRI may have the potential to improve the antenatal identification of small for gestational age. The aims of this study were to provide normal values of placental T2 in relation to gestational age at the time of MRI and to explore the correlation between placental T2 and birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A mixed cohort of 112 singleton pregnancies was retrieved from our placental MRI research database. MRI was performed at 23.6\u201041.3\u00a0weeks of gestation in a 1.5T system (TE (8): 50\u2010440\u00a0ms, TR: 4000\u00a0ms). Normal pregnancies were defined by uncomplicated pregnancies with normal obstetric outcome and birthweight deviation within \u00b11 SD of the expected for gestational age. The correlation between placental T2 and birthweight was investigated using the following outcomes; small for gestational age (birthweight \u2264\u22122 SD of the expected for gestational age) and birthweight deviation (birthweight <jats:italic>Z<\/jats:italic>\u2010scores).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In normal pregnancies (n\u00a0=\u00a027), placenta T2 showed a significant negative linear correlation with gestational age (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.91, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001) being 184\u00a0ms\u00a0\u00b1\u00a015.94\u00a0ms (mean\u00a0\u00b1\u00a0SD) at 20\u00a0weeks of gestation and 89\u00a0ms\u00a0\u00b1\u00a015.94\u00a0ms at 40\u00a0weeks of gestation. Placental T2 was significantly reduced among small\u2010for\u2010gestational\u2010age pregnancies (mean <jats:italic>Z<\/jats:italic>\u2010score \u22121.95, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Moreover, we found a significant positive correlation between placenta T2 deviation (<jats:italic>Z<\/jats:italic>\u2010score) and birthweight deviation (<jats:italic>Z<\/jats:italic>\u2010score) (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0.26, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides normal values of placental T2 to be used in future studies on placental MRI. Placental T2 is closely related to birthweight and may improve the antenatal identification of small\u2010for\u2010gestational\u2010age pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14057","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T09:09:51Z","timestamp":1606813791000},"page":"934-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Placental transverse relaxation time (T2) estimated by MRI: Normal values and the correlation with birthweight"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-6654","authenticated-orcid":false,"given":"Kristi B.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Pathology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna 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Clinical Engineering Central Denmark Region Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens B.","family":"Fr\u00f8kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Department of Radiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg 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