{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:37:37Z","timestamp":1788514657662,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fetal bradycardia due to sentinel events such as placental abruption, cord prolapse or uterine rupture is associated with an increased risk of acidemia at birth. In the absence of a sentinel event, data regarding neonatal prognosis are scarce, and it seems plausible that the depth of bradycardia might be associated with an increased risk of acidosis at birth. The objective was to determine whether the depth of bradycardia is associated with a higher risk of umbilical artery acidemia at birth in term singleton pregnancies requiring cesarean delivery during labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A retrospective comparative study of all cesarean deliveries for bradycardia in an academic tertiary center in the 6\u2010year period of 2013\u20102018, among term singleton pregnancies. Bradycardia associated with a sentinel event such as placental abruption, cord prolapse or uterine rupture, were excluded. The nadir of the bradycardia was defined as the lowest fetal heart rate baseline lasting at least 3 minutes during bradycardia. Women who delivered an infant with an umbilical pH at birth &lt;7.00 (acidosis group) were compared with women who delivered an infant with an umbilical pH at birth \u22657.00 (non\u2010acidosis group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 111 eligible cases, 32 women in the acidosis group were compared with 79 in the non\u2010acidosis group. The median nadir of the bradycardia was lower in the acidosis than in the non\u2010acidosis group (60\u00a0bpm, interquartile range [56\u201065] vs 70 [60\u201076], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). A bradycardia nadir &lt;60\u00a0bpm emerged as the optimal threshold for predicting acidemia and was more frequently observed in the acidosis than in the non\u2010acidosis group (10 [31%] vs 10 [13%], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). In the multivariable analysis, a nadir &lt;60\u00a0bpm was independently associated with an umbilical artery pH &lt;7.00 (adjusted OR 3.16, 95% CI 1.10\u20109.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A bradycardia nadir &lt;60\u00a0bpm was associated with a tripled risk of umbilical artery acidemia at birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14061","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T12:25:19Z","timestamp":1607948719000},"page":"964-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fetal heart rate nadir during bradycardia and umbilical artery acidemia at birth"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-3749","authenticated-orcid":false,"given":"Jacques","family":"Lepercq","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology of Port Royal Cochin Hospital Assistance Publique \u2010 H\u00f4pitaux de Paris Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My\u2010Anh","family":"Nghiem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology of Port Royal Cochin Hospital Assistance Publique \u2010 H\u00f4pitaux de Paris Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Goffinet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology of Port Royal Cochin Hospital Assistance Publique \u2010 H\u00f4pitaux de Paris Paris Descartes University Paris France"},{"name":"INSERM Unit 953 Epidemiological Research Unit on Perinatal Health and Women\u2019s Health Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181bc6e15"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2000.7079"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.05.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31822f1713"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181aef106"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000445580.65983.d2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.01945.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08035250510036507"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2007.02.008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000132"},{"key":"e_1_2_8_14_1","volume-title":"American College of Obstetricians and Gynecologists. Intrapartum and postpartum care of women. Guidelines for perinatal care","author":"American Academy of Pediatrics","year":"2012"},{"key":"e_1_2_8_15_1","unstructured":"National Institute for Health and Care Excellence.Intrapartum care for healthy women and babies. (NICE guideline 190).https:\/\/www.nice.org.uk\/guidance\/cg190. Accessed February 21 2017."}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.14061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:01:12Z","timestamp":1693551672000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/aogs.14061"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14061","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,26]]},"assertion":[{"value":"2020-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}