{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:30:21Z","timestamp":1775064621154,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study is to evaluate the quality of the endometrial sample obtained by office endometrial aspiration when performed before or after saline contrast sonohysterography (SCSH) in women with postmenopausal bleeding and a thickened endometrium. To conduct a complete, minimally invasive and cost\u2010effective diagnostic workup in women with postmenopausal bleeding and a thickened endometrium, ideally both the office endometrial sampling and SCSH are performed. However, it is not known whether both tests affect each other when performed one after another.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Women with postmenopausal bleeding and an endometrial thickness &gt;4\u00a0mm were eligible. Women were randomized into two groups: one group received endometrial aspiration before SCSH, the other group received SCSH before endometrial aspiration. The primary outcome was the proportion of sufficient endometrial samples. Reliability of the SCSH images and pain during procedures were secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the inclusion period, 513 eligible women with postmenopausal bleeding visited the participating hospitals, 293 of whom received information about the study. Of these women, 232 (79%) agreed to participate. In the SCSH\u2010aspiration group, 65 women (59%) had a sufficient endometrial sample compared with 70 (67%) in the aspiration\u2010SCSH group (odds ratio 1.46, 95% CI 0.83\u20102.54, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.19). The proportion of reliable sonographic images was significantly higher in the SCSH\u2010aspiration group (n\u00a0=\u00a088, 87%) compared with the aspiration\u2010SCSH group (n\u00a0=\u00a071, 74%) (OR 2.38, 95% CI 1.38\u20104.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) in the per protocol analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that the quality of an endometrial sample in women with postmenopausal bleeding is not affected by SCSH. Both procedures can be performed in one outpatient visit to perform an optimal diagnostic workup.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14086","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T10:50:32Z","timestamp":1610880632000},"page":"1258-1264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endometrial sampling before or after saline contrast sonohysterography in women with postmenopausal bleeding (ESPRESSO trial): A multicenter randomized controlled trial"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-1805","authenticated-orcid":false,"given":"Albertine J.","family":"Vroom","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Maxima Medisch Centrum Veldhoven The Netherlands"},{"name":"Department of Obstetrics and Gynecology GROW\u2010School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology GROW\u2010School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies Y.","family":"Bongers","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Maxima Medisch Centrum Veldhoven The Netherlands"},{"name":"Department of Obstetrics and Gynecology GROW\u2010School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianne C.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology GROW\u2010School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4701-3311","authenticated-orcid":false,"given":"Bart J.","family":"Pielkenrood","sequence":"additional","affiliation":[{"name":"Department of Imaging and Oncology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy M. A. J.","family":"Geomini","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Maxima Medisch Centrum Veldhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehalennia","family":"van Hanegem","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Gynecology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.11.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.12.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14126"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f74864"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20229"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200206000-00010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(03)80761-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2008.06.012"},{"key":"e_1_2_9_10_1","first-page":"304","article-title":"Endometrial SamPling befoRe or aftEr Saline infusion SOnography (ESPRESSO Trial): a national survey and a study protocol of a multicenter RCT","volume":"69","author":"Vroom AJ","year":"2017","journal-title":"Minerva Ginecol"},{"key":"e_1_2_9_11_1","first-page":"502","article-title":"Transvaginale contrastechoscopie van de uterus in de diagnostiek van abnormaal uterien bloedverlies: Minder hysteroscopieen nodig [Transvaginal contrast sonography of the uterus in the diagnosis of abnormal uterine blood loss: less hysteroscopies needed]","volume":"147","author":"Br\u00f6lmann HAM","year":"2003","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.801210.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.06.007"},{"key":"e_1_2_9_14_1","first-page":"1539","article-title":"Doelmatigheid van watercontrastechografie ter beoordeling van het cavum uteri [Efficiency of saline contrast hysterosonography for evaluating the uterine cavity]","volume":"147","author":"Kroon CD","year":"2003","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00472.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5263"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.14086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T05:17:59Z","timestamp":1705727879000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/aogs.14086"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14086","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,7]]},"assertion":[{"value":"2020-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}