{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:53:46Z","timestamp":1775390026643,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The introduction of the non\u2010invasive prenatal test (NIPT) has shifted the prenatal screening landscape. Countries are exploring ways to integrate NIPT in their national prenatal screening programs, either as a first\u2010 or second\u2010tier test. This study aimed to describe how the uptake of fetal aneuploidy screening changed after the introduction of NIPT as a second\u2010tier and as a first\u2010tier test within the national prenatal screening program of the Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A population\u2010based register study in the Netherlands, recording uptake of fetal aneuploidy screening. Data from all pregnant women choosing to have the first\u2010trimester combined test (FCT) or first\u2010tier NIPT between January 2007 and March 2019 were retrospectively collected using national registration systems. Uptake percentages for fetal aneuploidy screening (FCT and NIPT) were calculated and stratified by region and maternal age. Statistical significance was determined using trend analysis and chi\u2010squared tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2007 and 2013 FCT uptake increased from 14.8% to 29.5% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004). In April 2014 NIPT was introduced as a second\u2010tier test for high\u2010risk women after FCT (TRIDENT\u20101 study). FCT uptake rose from 29.5% in 2013 to 34.2% in 2015 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). After the introduction of NIPT as a first\u2010tier test for all women in April 2017 (TRIDENT\u20102 study), FCT uptake declined significantly from 35.8% in 2016 to 2.6% in 2018 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). NIPT uptake increased to 43.4% in 2018. Regionally, NIPT uptake ranged from 31.8% to 67.9%. Total uptake (FCT and NIPT) between 2007 and 2018 increased significantly from 14.8% to 45.9% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). However, total uptake stabilized at 46% for both years of TRIDENT\u20102 (April 2017\u2010March 2019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An increase in total fetal aneuploidy screening uptake up to 45.9% was observed after the introduction of NIPT. Uptake appears to have stabilized within a year after introducing first\u2010tier NIPT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14091","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T23:30:07Z","timestamp":1611099007000},"page":"1265-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Uptake of fetal aneuploidy screening after the introduction of the non\u2010invasive prenatal test: A national population\u2010based register study"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-588X","authenticated-orcid":false,"given":"Karuna R. M.","family":"van der Meij","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics and Amsterdam Reproduction &amp; Development Research Institute Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurike","family":"de Groot\u2010van Mooren","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Amsterdam Reproduction &amp; Development Research Institute Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen W. S.","family":"Carbo","sequence":"additional","affiliation":[{"name":"Center for Health Protection National Institute for Public Health and the Environment Bilthoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mijntje J.","family":"Pieters","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology GROW School of Oncology and Developmental Biology, Maastricht University Medical Center Maastricht the Netherlands"},{"name":"Foundation Prenatal Screening Southeast Region of the Netherlands, Maastricht, the Netherlands On Behalf of the Regional Centers for Prenatal Screening Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Rodenburg","sequence":"additional","affiliation":[{"name":"Center for Health Protection National Institute for Public Health and the Environment Bilthoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-4563","authenticated-orcid":false,"given":"Erik A.","family":"Sistermans","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics and Amsterdam Reproduction &amp; Development Research Institute Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-5544","authenticated-orcid":false,"given":"Martina C.","family":"Cornel","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics and Amsterdam Reproduction &amp; Development Research Institute Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-0597","authenticated-orcid":false,"given":"Lidewij","family":"Henneman","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics and Amsterdam Reproduction &amp; Development Research Institute Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Dutch NIPT Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407349"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4945"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20353"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4637"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004084"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093559"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13841"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-437"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/medethics-2017-104729"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.57"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2618-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.10.005"},{"key":"e_1_2_10_15_1","unstructured":"LiefersJ CruijsbergJ AtsmaF.Monitor 2017 Prenatale screening op down\u2010 edwards en patausyndroom en het Structureel EchoscopischOnderzoek. 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