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Here we explore the development of the first LNG\u2010IUS (Mirena\u00ae) and the early clinical trials that demonstrated its potential. We highlight the contraceptive and therapeutic benefits of Mirena\u00ae, and discuss how clinical practice has been changed since the introduction of LNG\u2010IUS and other long\u2010acting reversible contraceptive methods. The history of Mirena\u00ae is rich in innovation and has also paved the way to the development of smaller intrauterine systems with lower hormone doses. Along with Mirena\u00ae, these newer LNG\u2010IUS contribute to improving contraceptive choices for women, allowing them to select the option that is right for them and that meets their needs no matter their age, parity or circumstances.<\/jats:p>","DOI":"10.1111\/aogs.14110","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T19:07:25Z","timestamp":1612552045000},"page":"614-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Thirty years of mirena: A story of innovation and change in women\u2019s healthcare"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1444","authenticated-orcid":false,"given":"Kristina","family":"Gemzell\u2010Danielsson","sequence":"first","affiliation":[{"name":"Department of Women and Children\u2019s Health Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Kubba","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Caetano","sequence":"additional","affiliation":[{"name":"Bayer Consumer Care AG Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Faustmann","sequence":"additional","affiliation":[{"name":"Bayer AG Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeva","family":"Lukkari\u2010Lax","sequence":"additional","affiliation":[{"name":"Bayer OY Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-130X","authenticated-orcid":false,"given":"Oskari","family":"Heikinheimo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"United Nations Department of Economic and Social Affairs.The Sustainable Development Goals Report 2018. 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