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In this study, we tested machine learning as a novel tool for incorporating additional prognostic parameters into the conventional FIGO staging system for stratifying patients with epithelial ovarian carcinomas and evaluating their survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Cancer\u2010specific survival data for epithelial ovarian carcinomas were extracted from the Surveillance, Epidemiology, and End Results (SEER) program. Two datasets were constructed based upon the year of diagnosis. Dataset 1 (39\u00a0514 cases) was limited to primary tumor (T), regional lymph nodes (N) and distant metastasis (M). Dataset 2 (25\u00a0291 cases) included additional parameters of age at diagnosis (A) and histologic type and grade (H). The Ensemble Algorithm for Clustering Cancer Data (EACCD) was applied to generate prognostic groups with depiction in dendrograms. C\u2010indices provided dendrogram cutoffs and comparisons of prediction accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dataset 1 was stratified into nine epithelial ovarian carcinoma prognostic groups, contrasting with 10 groups from FIGO methodology. The EACCD grouping had a slightly higher accuracy in survival prediction than FIGO staging (C\u2010index\u00a0=\u00a00.7391 vs 0.7371, increase in C\u2010index\u00a0=\u00a00.0020, 95% confidence interval [CI] 0.0012\u20130.0027, <jats:italic>p<\/jats:italic> =\u00a01.8\u00a0\u00d7\u00a010<jats:sup>\u22127<\/jats:sup>). Nevertheless, there remained a strong inter\u2010system association between EACCD and FIGO (rank correlation\u00a0=\u00a00.9480, <jats:italic>p<\/jats:italic>\u00a0=\u00a06.1\u00a0\u00d7\u00a010<jats:sup>\u221215<\/jats:sup>). Analysis of Dataset 2 demonstrated that A and H could be smoothly integrated with the T, N and M criteria. Survival data were stratified into nine prognostic groups with an even higher prediction accuracy (C\u2010index\u00a0=\u00a00.7605) than when using only T, N and M.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EACCD was successfully applied to integrate A and H with T, N and M for stratification and survival prediction of epithelial ovarian carcinoma patients. Additional factors could be advantageously incorporated to test the prognostic impact of emerging diagnostic or therapeutic advances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14137","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T07:17:42Z","timestamp":1614928662000},"page":"1511-1519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A prognostic system for epithelial ovarian carcinomas using machine learning"],"prefix":"10.1111","volume":"100","author":[{"given":"Philip M.","family":"Grimley","sequence":"first","affiliation":[{"name":"Department of Pathology F. 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