{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:04:04Z","timestamp":1790661844386,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010428","name":"Innovation and Technology Fund","doi-asserted-by":"publisher","award":["ITS\/252\/17FX"],"award-info":[{"award-number":["ITS\/252\/17FX"]}],"id":[{"id":"10.13039\/501100010428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Our objectives were to compare the single\u2010line and two\u2010line methods of cervical length measurement in the first trimester of pregnancy and to evaluate the potential value of the first trimester cervical length measured by the two methods in predicting spontaneous preterm birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This was a prospective study in singleton pregnancies at 11+0 to 13+6<jats:sup>\u00a0<\/jats:sup>weeks of gestation. Cervical length was measured by two methods: (i) a linear distance between the two ends of the glandular area around the endocervical canal (single\u2010line method) and (ii) a sum of a linear distance from the internal os to the greatest cervical curvature and a linear distance from this point of the cervix to the external os (two\u2010line method). The screening performance of the first trimester cervical length measured by the two different methods for the prediction of spontaneous preterm delivery was assessed by receiver\u2010operating characteristics (ROC) curve analysis. The areas under the ROC (AUROC) were compared by De Long test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1484 consecutive singleton pregnancies were included in this study. Spontaneous preterm delivery at &lt;37\u00a0and &lt;32\u00a0weeks occurred in 75 cases (5.1%) and 12 cases (0.8%), respectively. The median cervical length measured by the single\u2010line method was significantly shorter than that by the two\u2010line method (33.5\u00a0vs 36.5\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Compared with the term delivery group, the median cervical length measured by the two\u2010line method was shorter in women with spontaneous delivery at &lt;32\u00a0weeks of gestation (36.5\u00a0vs 33.6\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). No significant difference in the median cervical length measured by the single\u2010line method was detected between the spontaneous preterm delivery and term delivery groups. Receiver\u2010operating\u2010characteristic curves demonstrated that cervical length measured by the two\u2010line method achieved better performance in predicting spontaneous delivery at &lt;32\u00a0weeks compared with the single\u2010line method (AUROC: 0.72 vs 0.61, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have demonstrated that the first trimester cervical length, measured by the two\u2010line approach, holds promise as a potential screening tool for early spontaneous preterm delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14138","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T17:00:15Z","timestamp":1615222815000},"page":"1305-1312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prediction of spontaneous preterm birth by cervical length in the first trimester of pregnancy: Comparison of two measurement methods"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-4066","authenticated-orcid":false,"given":"Qiaoli","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8726-2569","authenticated-orcid":false,"given":"Honglei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Suzhou Municipal Hospital Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kubi","family":"Appiah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Man","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010yun","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The First Affiliated Hospital of Kunming Medical University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piya","family":"Chaemsaithong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liona C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Chinese University of Hong Kong Hong Kong Hong 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