{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:02:40Z","timestamp":1791943360842,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Early\u2010onset fetal growth restriction is a pregnancy complication often coinciding with abnormal Doppler flow in the umbilical artery. Absent or reversed end\u2010diastolic flow in the umbilical artery is associated with adverse perinatal outcome. As the optimal management of this condition is unclear, the objective of this study was to analyze the time interval from admission to delivery of pregnancies with early\u2010onset fetal growth restriction, while pursuing a policy of postponing delivery unless active management of labor would be required because of fetal distress or maternal condition. We also assessed short\u2010 and long\u2010term perinatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this historical cohort study, all pregnant women with singleton pregnancies, admitted during 2004\u20132015 with early\u2010onset fetal growth restriction were included. Pregnancies with absent or reversed end\u2010diastolic flow (AREDF) were compared with pregnancies with a positive end\u2010diastolic Doppler flow (PEDF). Time until delivery was determined and perinatal outcome was assessed for both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our study, 111 women were allocated to the PEDF group and 109 to the AREDF group. In the AREDF group, fetal distress was more often an indication for delivery, in comparison with the PEDF group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). Median time until delivery in patients admitted between 26 and 28\u00a0weeks\u2019 gestation was 6+5 weeks in the PEDF group and 1+4 weeks in the AREDF group <jats:italic>(p<\/jats:italic>\u00a0=\u00a0.001). No statistically significant difference was found between the Doppler groups in the composite adverse neonatal outcome, which includes at least one of the following outcomes: infant respiratory distress syndrome, sepsis, bronchopulmonary dysplasia, necrotizing enterocolitis, intraventricular hemorrhage &gt;grade 2, periventricular leukomalacia and perinatal death (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.63).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, comprising pregnancies with early\u2010onset fetal growth restriction, fetal distress was observed more frequently in the AREDF group with the consequence of delivery at an earlier stage of gestation, compared with the PEDF group. AREDF was not associated with increased perinatal morbidity and mortality compared with PEDF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14142","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T19:55:13Z","timestamp":1615406113000},"page":"1430-1438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outcome of early\u2010onset fetal growth restriction with or without abnormal umbilical artery Doppler flow"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9767-4903","authenticated-orcid":false,"given":"Diana","family":"Gairabekova","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Obstetrics and Prenatal Medicine Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9187-244X","authenticated-orcid":false,"given":"Joost","family":"van Rosmalen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-9362","authenticated-orcid":false,"given":"Johannes J.","family":"Duvekot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Obstetrics and Prenatal Medicine Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.082297"},{"key":"e_1_2_9_3_1","unstructured":"Dutch Society of Obstetrics and Gynaecology (NVOG).Foetale groeirestrictie\/\"Fetal growth restriction.2017. Available from:https:\/\/www.nvog.nl\/wp\u2010content\/uploads\/2017\/12\/Foetate\u2010groeirestricie\u2010FGR\u201015\u201009\u20102017.pdf."},{"key":"e_1_2_9_4_1","unstructured":"Dutch Society of Obstetrics and Gynaecology (NVOG).Nota: Verwijzing naar een perinatologisch centrum\/\"Referral to a perinatal centre\".2007[J.J. Duvekot on behalf of the Otterlo working group]. Available from:https:\/\/www.nvog.nl\/wp\u2010content\/uploads\/2017\/12\/Nota\u2010Verwijzing\u2010naar\u2010een\u2010perinatologisch\u2010centrum\u20101.0\u201019\u201009\u20102007.pdf."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-016-0041-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355525"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91342-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90457-X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11092.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70285-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02014.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2018.01.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.06.020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13190"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309021113"},{"key":"e_1_2_9_18_1","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"3","author":"Roberts D","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31002-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90529-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.899574"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23101"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.07.008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253215.79121.75"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.14142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:38:39Z","timestamp":1693341519000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/aogs.14142"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14142","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]},"assertion":[{"value":"2020-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}