{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:51:38Z","timestamp":1794019898297,"version":"4.8.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Iron deficiency during pregnancy is a global health problem and is associated with adverse pregnancy outcomes. The aim of this randomized, double\u2010blind, placebo\u2010controlled study was to evaluate the effect of\n                      <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                      299v (Lp299v, 10\n                      <jats:sup>10<\/jats:sup>\n                      colony forming units), 4.2\u00a0mg iron, 12\u00a0mg ascorbic acid and 30\u00a0\u00b5g folic acid (Lp) on iron status in healthy, non\u2010anemic, pregnant Swedish women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      A total of 326 women were randomized to receive Lp (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0161) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0165) twice daily from gestational week 10\u201312 until end of pregnancy or until the potential start of iron therapy. The primary endpoint was serum ferritin at week 28.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Intake of Lp attenuated the decrease in serum ferritin from baseline to week 28 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) and week 35 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u02c2\u00a00.001) and resulted in reduced prevalence of iron deficiency (59% vs 78%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017) and iron deficiency anemia (7.4% vs 21%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.023) at week 35. Intake of Lp also resulted in beneficial effects on the soluble transferrin receptor (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011) and total body iron (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u02c2\u00a00.001) at week 35. Gestational length and birthweight were comparable between groups. The proportion of women reporting adverse events during the study was comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intake of Lp from early pregnancy was safe, attenuated the loss of iron stores and improved iron status in healthy pregnant women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14153","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T19:23:50Z","timestamp":1619033030000},"page":"1602-1610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The effect of\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-3721","authenticated-orcid":false,"given":"Ulrika","family":"Axling","sequence":"first","affiliation":[{"name":"Probi AB Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"\u00d6nning","sequence":"additional","affiliation":[{"name":"Probi AB Lund Sweden"},{"name":"Biomedical Nutrition, Pure and Applied Biochemistry Center for Applied Life Sciences Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titti","family":"Martinsson Niskanen","sequence":"additional","affiliation":[{"name":"Probi AB Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Larsson","sequence":"additional","affiliation":[{"name":"Probi AB Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R.","family":"Hansson","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences Lund Department of Obstetrics and Gynecology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Hulth\u00e9n","sequence":"additional","affiliation":[{"name":"Institute of Medicine Department of Internal Medicine and Clinical Nutrition Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.11.002"},{"key":"e_1_2_11_3_1","volume-title":"The Global Prevalence of Anemia in 2011","author":"World Health 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