{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:26:49Z","timestamp":1792290409948,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Data from the Italian Cystic Fibrosis Registry concerning pregnancies in the period 2010\u20132015 were used to investigate the association between the preconception clinical status and perinatal outcomes of women with cystic fibrosis (CF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      The assessed clinical variables were genotype, age at the time of conception, body mass index (BMI) and the percentage of predicted forced expiratory volume in the first second (ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      ). The analyzed outcomes were gestational age, birthweight and the frequency of cesarean deliveries. A generalized linear mixed model (GLIMMIX) was used to evaluate the association between type of delivery and age at the time of becoming pregnant, BMI, ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      and gestational age. Robust multivariable regression was used to evaluate the relation between gestational age and age at the time of becoming pregnant, BMI and ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      . Multivariable linear regression was performed to verify association between birthweight and BMI, and ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Complete information concerning mother and child was available for 56 completed pregnancies. Median age at the time of conception was 30.8\u00a0years (range: 18.7\u201342.3); median BMI was 21.5\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (range: 16.5\u201326.8); and median ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      was 73.9 (range: 30\u2013128). In all, 31 women (55.36%) had a genotype consisting of two CF\u2010causing variants. Eight were homozygous for the\n                      <jats:italic>F508del<\/jats:italic>\n                      mutation (14.28% of the total). The median duration of pregnancy was 37\u00a0weeks (range: 31\u201341) and the frequency of prematurity (&lt;37\u00a0weeks of gestational age) was 28.30%. Median birthweight was 2910\u00a0g (range: 1300\u20133650). The overall frequency of cesarean sections was 63.64%. A low preconception ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      was associated with prematurity (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014), and birthweight was positively related to ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04). There was no association between the clinical variables or gestational age and the type of delivery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Maternal preconceptional respiratory function correlates with the duration of pregnancy and the birthweight of newborns. Cesarean deliveries are also frequent among young women with CF with normal respiratory function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14190","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T07:25:43Z","timestamp":1621841143000},"page":"1439-1444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Perinatal outcomes in women with cystic fibrosis: Data from the Italian Cystic Fibrosis Registry"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-8125","authenticated-orcid":false,"given":"Rita F.","family":"Padoan","sequence":"first","affiliation":[{"name":"Cystic Fibrosis Center Department of Pediatrics University of Brescia Brescia Italy"},{"name":"Scientific Board Italian Cystic Fibrosis Registry Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Quattrucci","sequence":"additional","affiliation":[{"name":"Scientific Board Italian Cystic Fibrosis Registry Rome Italy"},{"name":"Italian League of Cystic Fibrosis ONLUS\u2010LIFC Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Amato","sequence":"additional","affiliation":[{"name":"Italian League of Cystic Fibrosis ONLUS\u2010LIFC Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Scientific Board Italian Cystic Fibrosis Registry Rome Italy"},{"name":"National Center of Rare Diseases Interdepartmental Undiagnosed Rare Diseases Unit Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-415X","authenticated-orcid":false,"given":"Donatello","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Scientific Board Italian Cystic Fibrosis Registry Rome Italy"},{"name":"Cystic Fibrosis Center Hospital San Carlo Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-9171","authenticated-orcid":false,"given":"Giuseppe","family":"Campagna","sequence":"additional","affiliation":[{"name":"Italian League of Cystic Fibrosis ONLUS\u2010LIFC Rome Italy"},{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Faculty of Medicine and Psychology La Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.11.019"},{"key":"e_1_2_11_3_1","unstructured":"ZolinA NaehrlichL vanRensJ.ECFSPR Annual Report 2015 2017."},{"issue":"4","key":"e_1_2_11_4_1","first-page":"1","article-title":"Rapporto 2015\u20102016 [Italian Cystic Fibrosis Registry (ICFR). 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