{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T16:44:18Z","timestamp":1787417058522,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hyperemesis gravidarum (HG) complicates 1% of pregnancies and has a major impact on maternal quality of life and well\u2010being. We know very little about HG\u2019s long\u2010term impact after an affected pregnancy, including recurrence rates in future pregnancies, which is essential information for women considering subsequent pregnancies. In this study, we aimed to prospectively measure the recurrence rate of HG and the number of postponed and terminated subsequent pregnancies due to HG. We also aimed to evaluate if there were predictive factors that could identify women at increased risk for HG recurrence, and postponing and terminating subsequent pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We conducted a prospective cohort study. A total of 215 women admitted for HG to public hospitals in the Netherlands were enrolled in the original MOTHER randomized controlled trial and associated observational cohort. Seventy\u2010three women were included in this follow\u2010up study. Data were collected through an online questionnaire. Recurrent HG was defined as vomiting symptoms accompanied by any of the following: multiple medication use, weight loss, admission, tube feeding or if nausea and vomiting symptoms were severe enough to affect life and\/or work. Outcome measures were recurrence, postponing, and termination rates due to HG. Univariable logistic regression analysis was used to identify predictive factors associated with HG recurrence, and postponing and terminating subsequent pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five women (48%) became pregnant again of whom 40% had postponed their pregnancy due to HG. HG recurred in 89% of pregnancies. One woman terminated and eight women (23%) considered terminating their pregnancy because of recurrent HG. Twenty\u2010four out of 38 women did not get pregnant again because of HG in the past. Univariable logistic regression analysis identifying possible predictive factors found that having a western background was associated with having weight loss due to recurrent HG in subsequent pregnancies (odds ratio 12.9, 95% CI 1.3\u2013130.5,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High rates of HG recurrence and a high number of postponed pregnancies due to HG were observed. Women can be informed of a high chance of recurrence to enable informed family planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14197","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T11:39:40Z","timestamp":1621942780000},"page":"1636-1643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Recurrence, postponing pregnancy, and termination rates after hyperemesis gravidarum: Follow up of the MOTHER study"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-5293","authenticated-orcid":false,"given":"Kelly","family":"Nijsten","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Clinical Epidemiology, Biostatistics and Bioinformatics Amsterdam University Medical Centers, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Dean","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"},{"name":"Pregnancy Sickness Support Bodmin UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efs M.","family":"van der Minnen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke M. J.","family":"Bais","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Noordwest Ziekenhuisgroep Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Ris\u2010Stalpers","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology Amsterdam University Medical Centers, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"van Eekelen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk A.","family":"Bremer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Reinier de Graaf Hospital Delft the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"van der Ham","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Martini Hospital Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1653-0885","authenticated-orcid":false,"given":"Wieteke M.","family":"Heidema","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjoke","family":"Huisjes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gelre Hospital Apeldoorn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Kleiverda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Flevo Hospital Almere the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone M.","family":"Kuppens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith O. E. H.","family":"van Laar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology M\u00e1xima Medical Center Veldhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josje","family":"Langenveld","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zuyderland Hospital Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flip","family":"van der Made","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Franciscus Gasthuis Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Papatsonis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amphia Hospital Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Jos\u00e9","family":"Pelinck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Scheper Hospital Emmen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula J.","family":"Pernet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Spaarne Gasthuis Haarlem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"van Rheenen\u2010Flach","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology OLVG Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbert J.","family":"Rijnders","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jeroen Bosch Hospital 's\u2010Hertogenbosch the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertina C. J.","family":"Scheepers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maastricht University Medical Center Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Vogelvang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Diakonessenhuis Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-550X","authenticated-orcid":false,"given":"Ben W.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Monash University Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa J.","family":"Roseboom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Clinical Epidemiology, Biostatistics and Bioinformatics Amsterdam University Medical Centers, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjette H.","family":"Koot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gelre Hospital Apeldoorn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris J.","family":"Grooten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Painter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam Amsterdam 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voor Volksgezondheid en Milieu.Gelijke behandeling bij zwangerschap op het werk [Equal treatment at work during pregnancy]. (in Dutch).2020.https:\/\/www.rijksoverheid.nl\/onderwerpen\/gelijke\u2010behandeling\u2010op\u2010het\u2010werk\/gelijke\u2010behandeling\u2010bij\u2010zwangerschap\u2010op\u2010het\u2010werk"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12852"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12514"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.14197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T14:40:02Z","timestamp":1692801602000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/aogs.14197"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14197","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"2021-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}