{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:53:12Z","timestamp":1790488392071,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The association between the degree of isolated gestational proteinuria and preeclampsia with severe features and other placental\u2010mediated complications is controversial. The aim of this study was to evaluate whether a higher isolated proteinuria level is associated with an increased frequency of preeclampsia with severe features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This retrospective cohort study included pregnant women who were past 24\u00a0weeks of gestation and were diagnosed as having new\u2010onset proteinuria \u2265300\u00a0mg in a 24\u2010h urine collection. Exclusion criteria included diagnosis of preeclampsia within 72\u00a0h from admission, chronic renal disease or chronic hypertension. The study population was divided into tertiles by proteinuria level and the association with preeclampsia with severe features was assessed in both bivariable and multivariable analysis. The main outcome measures was the development of preeclampsia with severe features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 165 women were diagnosed with isolated gestational proteinuria, and 38 (23.0%) of them developed preeclampsia with severe features. Women in the increasing proteinuria tertile were more likely to develop preeclampsia with severe features (5.5%, 21.8%, 41.8%, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). A multivariable logistic regression model controlling for background characteristics as well as gestational age at diagnosis, blood pressure, and kidney and liver function tests showed an increased risk of 14% to develop preeclampsia with severe features for every 500\u2010mg rise in proteinuria level (adjusted odds ratio\u00a0=\u00a01.14, 95% confidence interval 1.03\u20131.27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A higher isolated gestational proteinuria level was associated with an increased risk to develop preeclampsia with severe features among pregnant women past 24\u00a0weeks of gestation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14198","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T17:45:03Z","timestamp":1622137503000},"page":"1620-1626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Progression from isolated gestational proteinuria to preeclampsia with severe features"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-6321","authenticated-orcid":false,"given":"Yossi","family":"Tzur","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Tel Aviv Sourasky Medical Center Lis Hospital for Women Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Rimon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Tel Aviv Sourasky Medical Center Lis Hospital for Women Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Geva","sequence":"additional","affiliation":[{"name":"The Hebrew University Hadassah Medical School Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Herzlich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Tel Aviv Sourasky Medical Center Lis Hospital for Women Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Kupferminc","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Tel Aviv Sourasky Medical Center Lis Hospital for Women Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.05.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000253301.55009.ac"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00395.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076083"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.84"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.136151"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.138"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.009"},{"key":"e_1_2_11_12_1","first-page":"311","article-title":"Birthweight standards in the live\u2010born population in Israel","volume":"7","author":"Dollberg S","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0776-9"},{"key":"e_1_2_11_14_1","first-page":"1765","article-title":"The outcome of pregnancy with new onset proteinuria without hypertension: retrospective observational study","volume":"29","author":"Ekiz A","year":"2016","journal-title":"J Matern Neonatal Med"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022115"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12915"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2008.062"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-004870"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00071.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-7-10"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003018"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.12.013"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.14198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T18:39:45Z","timestamp":1692815985000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,19]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/aogs.14198"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14198","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,19]]},"assertion":[{"value":"2021-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}