{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:58:57Z","timestamp":1782626337100,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Post\u2010date pregnancies have an increased risk of adverse delivery outcome. Our aim was to explore the association between placenta\u2010associated circulating biomarkers and composite adverse delivery outcome of a likely placental cause in clinically healthy post\u2010date pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Women with healthy singleton post\u2010date pregnancies between 40<jats:sup>+2<\/jats:sup> and 42<jats:sup>+2<\/jats:sup>\u00a0weeks of gestation were recruited to this prospective, observational study conducted at Oslo University Hospital, Norway (NCT03100084). Placental growth factor (PlGF) and soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) were measured in the maternal serum samples closest to delivery. The composite adverse delivery outcome included fetal acidemia, low Apgar score (&lt;4 at 1\u00a0min or &lt;7 at 5\u00a0min), asphyxia, fetal death, assisted ventilation for more than 6\u00a0h, meconium aspiration, hypoxic\u2013ischemic encephalopathy, therapeutic hypothermia, operative delivery due to fetal distress, or pathological placental histology findings. Two study\u2010independent senior consultant obstetricians blinded to biomarker results concluded, based on clinical expert opinion, whether the adverse delivery outcomes were most likely associated with placental dysfunction (\u201clikely placental cause\u201d) or not. Means were compared using one\u2010way analysis of variance and Bonferroni corrected pairwise comparisons between groups. Receiver operating characteristic (ROC) curves assessed the predictive ability of PlGF, sFlt\u20101\/PlGF ratio, and PlGF &lt;10th centile after adjustment for gestational age at blood sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 501 pregnancies reviewed for predefined adverse delivery outcomes and for a likely placental cause, 468 were healthy pregnancies and subsequently assigned to either the \u201cuncomplicated\u201d (no adverse outcome, <jats:italic>n<\/jats:italic>\u00a0=\u00a0359), \u201cintermediate\u201d (non\u2010placental cause\/undetermined, <jats:italic>n<\/jats:italic>\u00a0=\u00a090), or \u201ccomplicated\u201d (likely placental cause, <jats:italic>n<\/jats:italic>\u00a0=\u00a019) group.<\/jats:p><jats:p>There was a significant difference in mean PlGF and sFlt\u20101\/PlGF ratio between the \u201ccomplicated\u201d, \u201cintermediate\u201d, and \u201cuncomplicated\u201d groups (108, 185, and 179\u00a0pg\/mL, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001; and 48.3, 23.4, and 24.6, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002, respectively). There was a higher proportion of PlGF concentration &lt;10th centile in the \u201ccomplicated\u201d group compared with the \u201cintermediate\u201d and \u201cuncomplicated\u201d groups (42.1% vs. 11.1% and 9.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). The largest area under the ROC curve for predicting \u201ccomplicated\u201d outcome was achieved by PlGF concentration and gestational age at blood sampling (0.76; 95% CI 0.65\u20130.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In clinically healthy post\u2010date pregnancies, an antiangiogenic pre\u2010delivery profile (lower PlGF level and higher sFlt\u20101\/PlGF ratio) was associated with composite adverse delivery outcome of a likely placental cause.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14223","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T09:37:27Z","timestamp":1625218647000},"page":"1893-1901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The association between placenta\u2010associated circulating biomarkers and composite adverse delivery outcome of a likely placental cause in healthy post\u2010date pregnancies"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-4468","authenticated-orcid":false,"given":"Sophie","family":"Bowe","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology Oslo University Hospital, Ullev\u00e5l Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Mitlid\u2010Mork","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology Oslo University Hospital, Ullev\u00e5l Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoniya","family":"Georgieva","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's and Reproductive Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon M.","family":"Gran","sequence":"additional","affiliation":[{"name":"Oslo Center for Biostatistics and Epidemiology University of Oslo and Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W. G.","family":"Redman","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's and Reproductive Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Cathrine","family":"Staff","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology Oslo University Hospital, Ullev\u00e5l Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4160-3978","authenticated-orcid":false,"given":"Meryam","family":"Sugulle","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology Oslo University Hospital, Ullev\u00e5l Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00837-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349709024606"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002838"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6131"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.12.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240473"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.10.007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18981"},{"key":"e_1_2_11_11_1","volume-title":"WHO Recommendations: Induction of Labour at or Beyond Term","author":"World Health Organization","year":"2018"},{"key":"e_1_2_11_12_1","volume-title":"Induction of Labour \u2010 NICE Clinical Guideline 70","author":"National Institute for Health and Care Excellence","year":"2008"},{"key":"e_1_2_11_13_1","unstructured":"MorkenNH HaavaldsenC HeimstadR MurzakanovaG StokkeAM.Overtidig svangerskap [Postdate pregnancy] (in Norwegian). 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