{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:03:12Z","timestamp":1773090192458,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Maternal mental health conditions have been shown to affect perinatal outcomes negatively. However, knowledge on the impact of different types and severities of maternal mental health conditions is needed. The objective of this study was to determine the association between maternal mental health status and perinatal health outcomes in the infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This register\u2010based cohort study included all live\u2010born infants in Denmark born between 2000 and 2016. Exposed infants were grouped based on whether the mothers received mental health care in primary care settings only (minor conditions) or required specialized psychiatric intervention (moderate\u2013severe conditions) within 12\u00a0months before childbirth. Modified Poisson regression analyses were applied to produce adjusted risk ratios (aRRs) for each perinatal outcome of interest. The primary outcomes were neonatal mortality, 5\u2010minute Apgar scores &lt;7 and &lt;4 and newborn hospital admission during the neonatal period. Secondary outcomes included several neonatal morbidities such as respiratory distress syndrome and abstinence syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 952\u00a0071 infants were included in the analysis; 4.0% had mothers with minor mental health conditions and 2.9% had mothers with moderate\u2013severe conditions. The risk of neonatal death in exposed infants was aRR 1.08 (95% CI 0.93\u20131.27) for minor mental health conditions and aRR 0.93 (95% CI 0.78\u20131.11) for moderate\u2013severe conditions. Both exposure groups had increased risks of 5\u2010minute Apgar scores &lt;7 (minor: aRR 1.28, 95% CI 1.16\u20131.41; moderate\u2013severe: aRR 1.49, 95% CI 1.34\u20131.66); 5\u2010minute Apgar scores &lt;4 (minor: aRR 1.10, 95% CI 0.93\u20131.30; moderate\u2013severe: aRR 1.18, 95% CI 0.98\u20131.43), and hospital admission during the neonatal period (minor: aRR 1.20, 95% CI 1.17\u20131.23; moderate\u2013severe: aRR 1.22, 95% CI 1.19\u20131.26) along with several neonatal morbidities. An explicit high risk was seen for abstinence syndrome (minor: aRR 10.30, 95% CI 8.40\u201312.63; moderate\u2013severe: aRR 12.13, 95% CI 10.17\u201315.67).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infants of mothers with moderate\u2013severe and minor mental health conditions were at increased risks of multiple adverse perinatal outcomes. Effective supportive interventions to improve outcomes in both groups are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14241","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T03:08:26Z","timestamp":1629947306000},"page":"2019-2028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk of adverse perinatal outcomes in infants born to mothers with mental health conditions"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-064X","authenticated-orcid":false,"given":"Signe","family":"Heuckendorff","sequence":"first","affiliation":[{"name":"Department of Social Medicine Aalborg University Hospital Aalborg Denmark"},{"name":"Danish Center for Clinical Health Services Research (DACS) Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise F.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Fonager","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Faculty of Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2010.09.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.02.027"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12567"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.0934"},{"key":"e_1_2_11_6_1","unstructured":"JensenAR DavidsenM EkholmO ChristensenAI.Danskernes Sundhed \u2010 Den Nationale Sundhedsprofil 2017. 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