{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:56:38Z","timestamp":1774745798229,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Evidence about the consequences of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection in pregnancy is rapidly increasing; however, data on antibody response and risk of transmission during pregnancy and delivery are still limited. The aim of this study was to evaluate if SARS\u2010CoV\u20102 is detectable in vaginal swabs and whether antibodies against SARS\u2010CoV\u20102 are present in maternal and umbilical cord blood of pregnant women with confirmed SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A single\u2010unit prospective cohort study in Denmark including pregnant women with SARS\u2010CoV\u20102 infection confirmed by a pharyngeal swab between August 20, 2020, and March 1, 2021, who gave birth during the same period. All patients admitted to the maternity ward and antepartum clinic were screened for SARS\u2010CoV\u20102 infection. A maternal blood sample and vaginal swabs were collected at inclusion. If included antepartum, these samples were repeated intrapartum when an umbilical cord blood sample was also collected. Swabs were analyzed for SARS\u2010CoV\u20102 and blood samples were analyzed for SARS\u2010CoV\u20102 total antibodies. Placental and neonatal swabs as well as placental histopathological examinations were performed on clinical indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 28 women, of whom four had serious maternal or fetal outcomes including one case of neonatal death. Within the first 8\u00a0days after confirmed SARS\u2010CoV\u20102 infection, SARS\u2010CoV\u20102 was detectable in two vaginal swabs (2\/28) and SARS\u2010CoV\u20102 antibodies were detected in 1 of 13 women. From 16\u00a0days after confirmed infection, antibodies were observed in 19 of 21 of women. Antibodies in cord blood were not detected during the first 16\u00a0days after confirmed infection (<jats:italic>n<\/jats:italic>\u00a0=\u00a07). However, from 26\u00a0days, antibodies were present in 16 of 17 cord blood samples of seropositive mothers. Placental examination in two cases of severe fetal outcomes preceded by reduced fetal movements revealed SARS\u2010CoV\u20102 in swabs and severe histopathological abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SARS\u2010CoV\u20102 was detected in only 2 of 28 vaginal swabs within 8\u00a0days after confirmed infection in pregnant women. Our data suggest that maternal seroconversion occurs between days 8 and 16, whereas antibodies in cord blood of seropositive mothers were present in the majority from 26\u00a0days after confirmed infection. Additional data are needed regarding timing of seroconversion for the mother and appearance of antibodies in cord blood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14274","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T08:07:07Z","timestamp":1635754027000},"page":"2268-2277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A prospective cohort study of confirmed severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection during pregnancy evaluating SARS\u2010CoV\u20102 antibodies in maternal and umbilical cord blood and SARS\u2010CoV\u20102 in vaginal swabs"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4170-6558","authenticated-orcid":false,"given":"Julie","family":"Milbak","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Copenhagen University Hospital \u2010 North Zealand Hilleroed Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-1712","authenticated-orcid":false,"given":"Victoria M. 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M.","family":"Aabakke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Copenhagen University Hospital\u2014Holbaek Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Copenhagen University Hospital \u2010 Herlev and Gentofte Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Barfred","family":"Friis","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Copenhagen University Hospital \u2010 Herlev and Gentofte Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus A. 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