{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:35:22Z","timestamp":1788953722479,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fetal growth restriction is a major risk factor for adverse perinatal outcome. As most of the growth\u2010restricted fetuses are small for gestational age (SGA), an efficient antenatal screening method for SGA fetuses would have a major impact on perinatal health. The aim of this study was to compare the SGA prediction rate achieved with third\u2010trimester routine ultrasound estimation of fetal weight (EFW) with that obtained using ultrasound examination on indication. The secondary aim was to evaluate the clinical outcome in relation to the SGA screening method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>During 1995\u20132009, two perinatal centers in southern Sweden offered routine ultrasound examination at 32\u201334 gestational weeks to 99\u00a0265 women with singleton pregnancies. Of these, 59\u00a0452 (60%) underwent the ultrasound examination. The other population, comprising 24\u00a0868 pregnancies, was cared for in another three centers that used a risk\u2010based method with ultrasound examinations on indication only. Of them, 5792 (23%) underwent ultrasound examination at 32\u201336 gestational weeks. The deviation in the EFW from the expected one was expressed as the EFW <jats:italic>z<\/jats:italic>\u2010score, SGA EFW being defined as the EFW <jats:italic>z<\/jats:italic>\u2010score less than \u22122. SGA prediction ability was assessed by receiver operating characteristic (ROC) curves. Crude and adjusted risk ratios were calculated for selected variables of perinatal outcome when comparing the populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SGA prediction ability for routine ultrasound was high, area under the ROC curve was 0.90 (95% CI 0.89\u20130.91). For an EFW <jats:italic>z<\/jats:italic>\u2010score of \u22121, the sensitivity was 67.3% and specificity was 90.5% among routinely screened pregnancies; corresponding numbers in the ultrasound on indication population were 34.3% and 96.6%. The screened population had a lower risk of preterm birth, birthweight <jats:italic>z<\/jats:italic>\u2010score less than \u22123, and Apgar score less than 7 at 5\u00a0min with adjusted risk ratios 0.87 (95% CI 0.82\u20130.92), 0.75 (95% CI 0.61\u20130.92), and 0.77 (95% CI 0.68\u20130.87), respectively. No difference in perinatal mortality was detected. There were no differences in perinatal outcome between the two subcohorts of infants born SGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Third\u2010trimester routine ultrasound improves the detection of SGA antenatally compared with ultrasound performed on indication, but no convincing improvement in perinatal outcome was identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14278","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T11:01:11Z","timestamp":1635850871000},"page":"102-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Detection and clinical outcome of small\u2010for\u2010gestational\u2010age fetuses in the third trimester\u2014A comparison between routine ultrasound examination and examination on indication"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-6890","authenticated-orcid":false,"given":"Anna","family":"Bonnevier","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Obstetrics and Gynecology Ystad Hospital  Ystad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3837-6332","authenticated-orcid":false,"given":"Karel","family":"Mar\u0161\u00e1l","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-2630","authenticated-orcid":false,"given":"Karin","family":"K\u00e4ll\u00e9n","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department of Clinical Sciences Lund University  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