{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:05:06Z","timestamp":1790643906673,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Reproductive endocrinologists recommend selective multifetal pregnancy reduction (MFPR) to save at least one or two babies, because triplet pregnancy is known to increase the risk of miscarriage and preterm delivery. However, recently improved obstetric and neonatal care may affect pregnancy outcomes differently in triplet pregnancies, which could alter practice. We compared the maternal, perinatal, and long\u2010term outcomes of triplet pregnancies managed expectantly with those of pregnancies reduced to twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this retrospective cohort study, we reviewed the clinical records of 552 trichorionic triplet pregnancies for obstetric, perinatal, and neurodevelopmental outcomes, which consisted of the expectant management (EM) group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0225) and MFPR group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0327), in Seoul National University Hospital and CHA Bundang Medical Center from January 2006 to December 2018. Neuromotor development was evaluated using the Korean\u2010Ages and Stages Questionnaire, Bayley\u2010III tests, and\/or Gross Motor Function Measure. The two groups were compared for the following outcomes: (1) nonviable pregnancy loss before 23\u00a0weeks, (2) preterm birth before 32\u00a0weeks of gestation, (3) fetal and neonatal survival and (4) long\u2010term neurodevelopmental outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences in maternal age, body mass index, nulliparity or previous preterm birth between the two groups. The risk of nonviable pregnancy loss was lower in the EM group\u00a0than that in the MFPR group (2 [0.9%] vs 21 [6.4%], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). The risk of preterm delivery before 34\u00a0weeks of gestation was lower in the MFPR group (adjusted odds ratios [aOR]\u00a0=\u00a00.47, 95% confidence interval [CI] 0.30\u20130.73, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001).\u00a0The survival rate of neonates until discharge (644 [95.4%] vs 572 [87.5], <jats:italic>p\u00a0<\/jats:italic>&lt; 0.001)\u00a0and the rate of pregnancies with at least one survivor (220 [97.8%] vs 301 [92.0], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002)\u00a0were higher in the EM group than those in the MFPR group. In the MFPR group, the risk of developmental delay (aOR\u00a0=\u00a02.89, 95% CI 1.38\u20136.02, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) was higher.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In trichorionic triplet pregnancies, the possibility of EM to improve survival and reduce the risk of developmental delay has been shown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14281","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T05:43:03Z","timestamp":1636350183000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short\u2010term and long\u2010term outcomes of trichorionic triplet pregnancies with expectant management"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-0245","authenticated-orcid":false,"given":"Ji Yeon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology CHA Bundang Medical Center CHA University School of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2543-0408","authenticated-orcid":false,"given":"Seung Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2266-5188","authenticated-orcid":false,"given":"Mina","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-448X","authenticated-orcid":false,"given":"Sohee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Seoul Metropolitan Government Seoul National University Boramae Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-7981","authenticated-orcid":false,"given":"Subeen","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6270-5020","authenticated-orcid":false,"given":"Seung\u2010Ah","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-1736","authenticated-orcid":false,"given":"Jong Kwan","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Reproductive Medicine and Population Seoul National University Medical Research Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"Births: final data for 2016","volume":"67","author":"Martin JA","year":"2018","journal-title":"Natl Vital Stat 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