{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:23:44Z","timestamp":1793755424085,"version":"4.6.1"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008220","name":"Canadian Foundation for AIDS Research","doi-asserted-by":"publisher","award":["26\u2010021"],"award-info":[{"award-number":["26\u2010021"]}],"id":[{"id":"10.13039\/100008220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Antiretroviral therapy\u2010na\u00efve pregnant women living with HIV are at an increased risk for adverse pregnancy outcomes. It remains controversial whether this risk persists with antiretroviral therapy. We conducted a systematic review and meta\u2010analysis to evaluate whether pregnant women living with HIV and receiving antiretroviral therapy antenatally, are at an increased risk of adverse outcomes compared with HIV\u2010negative controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We searched MEDLINE, Embase, International Pharmaceutical Abstracts, EBM Reviews, PubMed (non\u2010MEDLINE records), EBSCO CINAHL Complete, Clarivate Web of Science, African Index Medicus, LILACS and Google Scholar for all observational studies comparing pregnant women living with HIV on antiretroviral therapy with HIV\u2010negative controls from 1 January 1994 to 10 August 2021 with no language or geographic restrictions. Perinatal outcomes included preterm birth (PTB), low birthweight, small\u2010for\u2010gestational age and preeclampsia. Using a random\u2010effects model we pooled raw data to generate odds ratio (OR) with 95% confidence intervals (CI) for each outcome. Sub\u2010analyses for high and low resource countries and time of antiretroviral therapy initiation were performed. This systematic review and meta\u2010analysis is registered with PROSPERO, number CRD42020182722.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 7900 citations identified, 27 were eligible for analysis (12 636 pregnant women living with HIV on antiretroviral therapy and 7\u00a0812\u00a0115 HIV\u2010negative controls). ORs (95% CI) of PTB (1.88 [1.63\u20132.17]), small\u2010for\u2010gestational age (1.60 [1.18\u20132.17]) and low birthweight (2.15 [1.58\u20132.92]) were significantly higher in pregnant women living with HIV than in HIV\u2010negative women, while the risk of preeclampsia (0.86 [0.57\u20131.30]) was comparable. The risk of PTB and low birthweight was higher in both high resource and low resource countries, while the risk of small\u2010for\u2010gestational age was higher only in the former. Preconceptional antiretroviral therapy was associated with a higher risk of PTB compared with antenatal initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pregnant women living with HIV on antiretroviral therapy have an increased risk of PTB, low birthweight and small\u2010for\u2010gestational age in high resource countries, as well as PTB and low birthweight in low income countries compared with HIV\u2010negative controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14282","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T04:46:33Z","timestamp":1635309993000},"page":"168-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Perinatal outcomes in women living with HIV\u20101 and receiving antiretroviral therapy\u2014a systematic review and 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