{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:46:50Z","timestamp":1776253610668,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Uncertainty remains about the most appropriate timing of induction of labor in late\u2010term pregnancies. To address this issue, this study aimed to compare the risk of neonatal morbidity and pregnancy\u2010 and birth\u2010related complications between gestational age (GA) 41<jats:sup>+4<\/jats:sup>\u201342<jats:sup>+0<\/jats:sup> and GA 41<jats:sup>+0<\/jats:sup>\u201341<jats:sup>+3<\/jats:sup>\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This nationwide registry\u2010based cohort study included singleton births without major congenital malformations, with registered GA, and with intended vaginal delivery at GA 41<jats:sup>+0<\/jats:sup>\u2013 42<jats:sup>+0<\/jats:sup>\u00a0weeks between 2009 and 2018 in Denmark. Logistic regression models were used to estimate the crude risk ratio and adjusted risk ratio (RR<jats:sub>A<\/jats:sub>) of neonatal and obstetric adverse outcomes in births at GA 41<jats:sup>+4<\/jats:sup>\u2013 42<jats:sup>+0<\/jats:sup>\u00a0weeks compared with GA 41<jats:sup>+0<\/jats:sup>\u2013 41<jats:sup>+3<\/jats:sup>\u00a0weeks. The results were adjusted for relevant confounders, including induction of labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A higher incidence of neonatal morbidity and birth complications was observed in births at GA 41<jats:sup>+4<\/jats:sup>\u201342<jats:sup>+0<\/jats:sup>\u00a0weeks than in births at GA 41<jats:sup>+0<\/jats:sup>\u201341<jats:sup>+3<\/jats:sup>\u00a0weeks. Neonatal morbidities included an increased risk of low Apgar score (Apgar 0\u20136 after 5\u00a0min; RR<jats:sub>A<\/jats:sub> 1.17, 95% confidence interval [CI] 1.01\u20131.34), meconium aspiration (RR<jats:sub>A<\/jats:sub> 1.25, 95% CI 1.06\u20131.48), need for respiratory support (continuous positive airway pressure; RR<jats:sub>A<\/jats:sub> 1.09, 95% CI 1.03\u20131.15), and a composite outcome of need for comprehensive treatment at a neonatal department or neonatal death (RR<jats:sub>A<\/jats:sub> 1.65, 95% CI 1.29\u20132.11). Birth complications included emergency cesarean section (RR<jats:sub>A<\/jats:sub> 1.17, 95% CI 1.14\u20131.21), severe lacerations (RR<jats:sub>A<\/jats:sub> 1.11, 95% Cl 1.04\u20131.17), and increased blood loss after birth (RR<jats:sub>A<\/jats:sub> 1.13, 95% CI 1.06\u20131.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Births at GA 41<jats:sup>+4<\/jats:sup>\u201342<jats:sup>+0<\/jats:sup>\u00a0weeks were associated with an increased risk of neonatal morbidity and birth complications compared with births at GA 41<jats:sup>+0<\/jats:sup>\u201341<jats:sup>+3<\/jats:sup>\u00a0weeks. The results of this study may aid clinicians in deciding when to recommend induction of labor in late\u2010term pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14299","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T08:05:21Z","timestamp":1638777921000},"page":"200-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Risk of complications in the late vs early days of the 42nd week of pregnancy: A nationwide cohort study"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0335-7991","authenticated-orcid":false,"given":"Charlotte Brix","family":"Andersson","sequence":"first","affiliation":[{"name":"Danish Center for Clinical Health Services Research (DACS)  Aalborg Denmark"},{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital\/Thisted  Thisted Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-0416","authenticated-orcid":false,"given":"Jesper Padkaer","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2787-0271","authenticated-orcid":false,"given":"S\u00f8ren Paaske","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Danish Center for Clinical Health Services Research (DACS)  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2830-8384","authenticated-orcid":false,"given":"Martin","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Center for Clinical Health Services Research (DACS)  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-106X","authenticated-orcid":false,"given":"Ulrik Schi\u00f8ler","family":"Kesmodel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000227783.65800.0f"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308553"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005785"},{"key":"e_1_2_10_5_1","article-title":"Induction of labour at or beyond 37 weeks\u2019 gestation","volume":"7","author":"Middleton P","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000452744.06088.48"},{"key":"e_1_2_10_7_1","unstructured":"Induction of Labour. 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