{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:31:37Z","timestamp":1771036297852,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009087","name":"Universidad Industrial de Santander","doi-asserted-by":"publisher","award":["758\u20102017"],"award-info":[{"award-number":["758\u20102017"]}],"id":[{"id":"10.13039\/501100009087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In October 2015, an epidemic of Zika began in Colombia\u2019s geographic areas with a high population of mosquitoes of the genus\u00a0<jats:italic>Aedes<\/jats:italic>. We aimed to describe the fetal brain ultrasound findings in pregnant women with active symptoms or a history of symptoms suggestive of Zika virus (ZIKV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Eligible pregnant women were tested with reverse transcriptase\u2010polymerase chain reaction (RT\u2010PCR) for ZIKV and followed prospectively using detailed anatomic ultrasound and transvaginal neurosonography to detect structural anomalies of the fetal central nervous system (CNS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 115 symptomatic women with a positive ZIKV RT\u2010PCR and 55 with a negative ZIKV RT\u2010PCR were enrolled in the study; CNS compromise of the fetus occurred in 22% and 17%, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.255). Callosal dysgenesis (14.5%) was the most frequent anomaly of the CNS, followed by microcephaly (13.6%) and neuronal migration disorders (8.3%). When symptomatic ZIKV RT\u2010PCR\u2010positive women were categorized by trimester of infection, CNS anomalies were present in 40% of first\u2010trimester infections, compared with 21% and 7% in second\u2010 and third\u2010trimester infections (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). CNS anomalies were also more severe in first\u2013trimester\u2010infected fetuses than in second\u2013 and third\u2013trimester\u2010infected fetuses. The high prevalence of CNS anomalies in fetuses of symptomatic ZIKV RT\u2010PCR negative women suggests a high rate of false\u2010negative cases and an even higher prevalence of CNS anomalies than observed in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of fetal CNS anomalies was higher than previously reported in the literature for both symptomatic RT\u2010PCR\u2010positive and \u2010negative pregnant women. Corpus callosum anomalies, microcephaly, neuronal migration disorders, and brain parenchymal hyperechogenicities were the most frequent CNS anomalies detected. In addition, CNS anomalies were more frequent and severe in infected fetuses during the first trimester of pregnancy than during the second or third trimester.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14301","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T09:16:48Z","timestamp":1639473408000},"page":"221-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fetal central nervous system anomalies according to RT\u2010PCR and trimester of maternal infection with Zika virus: A prospective cohort study"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-755X","authenticated-orcid":false,"given":"Luz \u00c1ngela","family":"Guti\u00e9rrez\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"School of Medicine Health Faculty Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Maternal\u2010Fetal Medicine Unit Hospital Universitario de Santander  Bucaramanga Colombia"},{"name":"Cl\u00ednica Materno Infantil San Luis  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-530X","authenticated-orcid":false,"given":"Carlos Hern\u00e1n","family":"Becerra\u2010Mojica","sequence":"additional","affiliation":[{"name":"School of Medicine Health Faculty Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Maternal\u2010Fetal Medicine Unit Hospital Universitario de Santander  Bucaramanga Colombia"},{"name":"Fundaci\u00f3n Oftalmol\u00f3gica de Santander Cl\u00ednica Carlos Ardila L\u00fclle  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2888-8200","authenticated-orcid":false,"given":"Mario Augusto","family":"Rojas","sequence":"additional","affiliation":[{"name":"School of Medicine Health Faculty Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Colombian Association of Neonatology Colombian Neonatal Research Network  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-6639","authenticated-orcid":false,"given":"Luis Alfonso","family":"D\u00edaz\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"School of Medicine Health Faculty Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Neonatal Unit Hospital Universitario de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-6523","authenticated-orcid":false,"given":"Luis Alfonso","family":"P\u00e9rez Vera","sequence":"additional","affiliation":[{"name":"School of Medicine Health Faculty Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Colombian Association of Neonatology Colombian Neonatal Research Network  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3771-8361","authenticated-orcid":false,"given":"Gustavo Adolfo","family":"Contreras Garc\u00eda","sequence":"additional","affiliation":[{"name":"School of Medicine Health Faculty Universidad Industrial de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5678-2425","authenticated-orcid":false,"given":"Luz Stella","family":"Pinilla Garc\u00eda","sequence":"additional","affiliation":[{"name":"School of Medicine Health Faculty Universidad Industrial de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30010-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805715"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww158"},{"key":"e_1_2_12_5_1","first-page":"1","article-title":"Microcephaly prevalence in infants born to zika virus\u2010infected women: a systematic review and meta\u2010analysis","volume":"18","author":"Campos Coelho AV","year":"2017","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17404"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S209213"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15831"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911023"},{"key":"e_1_2_12_11_1","unstructured":"Ministerio de Salud y Protecci\u00f3n Social de Colombia Bogota. Lineamientos para la gesti\u00f3n de los planes de contingencia para fiebre Zika y atenci\u00f3n cl\u00ednica en embarazadas con infecci\u00f3n por ZIKV y pacientes con complicaciones neurol\u00f3gicas y recomendaciones especiales. Actualizaci\u00f3n de la circular 043 de 2015. [Guidelines for the management of contingency plans for Zika fever and clinical care in pregnant women with ZIKV infection and patients with neurological complications and special recommendations. Update of circular 043 from 2015 Ministerio de Salud y Protecci\u00f3n Social de Colombia. Bogota 2016; Circular 0.https:\/\/www.minsalud.gov.co\/Paginas\/default.aspx"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0123-9392(12)70018-8"},{"key":"e_1_2_12_13_1","unstructured":"Ministerio de Salud y Protecci\u00f3n Social de Colombia Bogota. Gu\u00eda de pr\u00e1ctica cl\u00ednica (GPC) basada en la evidencia para la atenci\u00f3n integral de la s\u00edfilis gestacional y cong\u00e9nita. [Evidence\u2010based clinical practice guide (CPG) for the comprehensive care of gestational and congenital syphilis.] In Spanish. Ministerio de Salud y Proteccion Social. GPC\u20102014\u201041.2014.https:\/\/www.acin.org\/images\/guias\/GPC_Versioncorta_SIFILIS_IMPRESION_n.PDF"},{"key":"e_1_2_12_14_1","unstructured":"Ministerio de Salud y Protecci\u00f3n Social \u2010 Colciencias Bogota. Gu\u00edas de pr\u00e1ctica cl\u00ednica para la prevenci\u00f3n detecci\u00f3n temprana y tratamiento de las complicaciones del embarazo parto o puerperio. [Clinical practice guidelines for the prevention early detection and treatment of complications of pregnancy childbirth or the puerperium].In Spanish. 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