{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:05Z","timestamp":1792686425856,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of the study was to identify the obstetric risk factors for hypoxic\u2013ischemic encephalopathy (HIE) in infants with asphyxia at birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>This multicenter case\u2013control study covered the 5\u2010year period from 2014 through 2018 and included newborns \u226536\u00a0weeks of gestation with an umbilical pH at birth \u22647.0. Cases were newborns who developed moderate or severe HIE; they were matched with controls with pH \u22647.0 at birth over the same period without moderate or severe HIE. The factors studied were maternal, gestational, intrapartum, delivery\u2010related, and neonatal characteristics. A multivariable analysis was performed to study the maternal, obstetric, and neonatal factors independently associated with moderate or severe HIE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our review of the records identified 41 cases and 98 controls. Compared with controls, children with moderate or severe HIE had a lower 5\u2010min Apgar score, lower umbilical artery pH, and higher cord lactate levels at birth and at 1\u00a0h of life. Obstetric factors associated with moderate or severe HIE were the occurrence of an acute event (adjusted odds ratio [aOR] 6.4; 95% confidence interval [CI] 1.8\u201322.5), maternal fever (aOR 3.5; 95% CI 1.0\u201311.9), and thick meconium during labor (aOR 2.9; 95% CI 1.0\u20138.6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HIE is associated with a lower 5\u2010min Apgar score and with the severity of acidosis at birth and at 1\u00a0h of life. In newborns with a pH &lt;7.0 at birth, the occurrence of an acute obstetric event, maternal fever, and thick meconium are independent factors associated with moderate or severe HIE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.14326","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T03:39:25Z","timestamp":1648265965000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Risk factors for hypoxic\u2013ischemic encephalopathy in cases of severe acidosis: A case\u2013control study"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-0245","authenticated-orcid":false,"given":"Perrine","family":"Lorain","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Trousseau Hospital \u2013 Assistance Publique\u2010Hopitaux de Paris, Sorbonne University  Paris 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