{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:15:44Z","timestamp":1790813744987,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study evaluated the association between fetal heart rate variability (HRV) and the occurrence of hypoxic\u2013ischemic encephalopathy in a fetal sheep model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The experimental protocol created a hypoxic condition with repeated cord occlusions in three phases (A, B, C) to achieve acidosis to pH &lt;7.00. Hemodynamic, gasometric and HRV parameters were analyzed during the protocol, and the fetal brain, brainstem and spinal cord were assessed histopathologically 48\u00a0h later. Associations between the various parameters and neural injury were compared between phases A, B and C using Spearman's rho test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute anoxic\u2013ischemic brain lesions in all regions was present in 7\/9 fetuses, and specific neural injury was observed in 3\/9 fetuses. The number of brainstem lesions correlated significantly and inversely with the HRV fetal stress index (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.784; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) in phase C and with HRV long\u2010term variability (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.677; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.045) and short\u2010term variability (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.837; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) in phase B. The number of neurological lesions did not correlate significantly with other markers of HRV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neural injury caused by severe hypoxia was associated with HRV changes; in particular, brainstem damage was associated with changes in fetal\u2010specific HRV markers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14352","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T09:04:03Z","timestamp":1651568643000},"page":"758-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations between fetal heart rate variability and umbilical cord occlusions\u2010induced neural injury: An experimental study in a fetal sheep 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