{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:27:37Z","timestamp":1785461257699,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015459","name":"Danish Cancer Society Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In Denmark, women with a future childbearing desire diagnosed with cervical intraepithelial neoplasia grade 2 (CIN2) are recommended active surveillance instead of excisional treatment. However, we have limited and contradictory knowledge about how active surveillance of CIN2 may affect women emotionally. The aim of this study was to explore thoughts and emotional responses in women undergoing active surveillance of CIN2 and to explore how active surveillance may affect women\u2019s future childbearing desire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This qualitative study was conducted in the gynecological outpatient clinic, the Department of Obstetrics and Gynecology, G\u00f8dstrup Hospital, Denmark. Women of childbearing age undergoing active surveillance with colposcopy, biopsy and smear every 6 months due to CIN2 were eligible for enrollment. In\u2010depth semi\u2010structured interviews were conducted. The interviews were audiotaped and transcribed verbatim. A thematic analysis was performed using a phenomenological approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20 women were included. All women experienced nervousness and anxiety when they were diagnosed with CIN2 initially. Their main concern was whether they had cancer. Most women carried on with their everyday lives with only minor occasional worries about CIN2, often prompted just before check\u2010up. However, some women were particularly nervous and found the period between check\u2010ups frustrating and challenging. Women did not want to postpone their plans for pregnancy because of CIN2, but experienced the worries and check\u2010ups associated with active surveillance as disruptive elements in their family planning. Women preparing for fertility treatment had their startup unnecessarily delayed due to active surveillance of CIN2, as clinical guidelines were inconsistent across subspecialties. Various factors influenced women\u2019s emotional well\u2010being: life circumstances, information needs, and mental and physical discomfort during colposcopic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women felt that worries and check\u2010ups due to active surveillance of CIN2 were disrupting elements in their family planning, although they did not affect their every\u2010day life. Some women, however, were particularly anxious, demonstrating the importance of including women\u2019s experiences and preferences in clinical counseling. The fact that fertility treatment was delayed due inconsistent guidelines across subspecialties, suggests a need for a revision of current guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.14354","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T13:38:13Z","timestamp":1649165893000},"page":"616-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["\u201cI feel reassured, but there is no guarantee.\u201d How do women with a future childbearing desire respond to active surveillance of cervical intraepithelial neoplasia grade 2? A qualitative study"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-2994","authenticated-orcid":false,"given":"Joan","family":"Hansen","sequence":"first","affiliation":[{"name":"G\u00f8dstrup Hospital, NIDO Denmark  G\u00f8dstrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Kirkegaard","sequence":"additional","affiliation":[{"name":"Department of Public Health Programs University Research Clinic for Cancer Screening, Randers Regional Hospital  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Folmann","sequence":"additional","affiliation":[{"name":"G\u00f8dstrup Hospital, NIDO Denmark  G\u00f8dstrup Denmark"},{"name":"University College South Denmark  Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Folge","family":"Bungum","sequence":"additional","affiliation":[{"name":"G\u00f8dstrup Hospital, NIDO Denmark  G\u00f8dstrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-9827","authenticated-orcid":false,"given":"Anne","family":"Hammer","sequence":"additional","affiliation":[{"name":"G\u00f8dstrup Hospital, NIDO Denmark  G\u00f8dstrup Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO.Calling for coordinated action globally to eliminate cervical cancer.2018[cited 2022 14.02]. Available from:https:\/\/www.who.int\/reproductivehealth\/call\u2010to\u2010action\u2010elimination\u2010cervical\u2010cancer\/en\/"},{"key":"e_1_2_11_3_1","unstructured":"NORDCAN.International Agency for Research on Cancer. Denmark. Cervix uteri 2021. Available from:https:\/\/gco.iarc.fr\/media\/nordcan\/factsheets\/91\/en\/countries\/208\/cervix_uteri\u2010190\u2010denmark\u2010208.pdf"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.12.013"},{"key":"e_1_2_11_5_1","first-page":"2157","article-title":"Effect of organized screening on incidence and mortality of cervical cancer in Denmark","volume":"49","author":"Lynge E","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.290"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.LGT200570"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k499"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16081"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000604"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000525"},{"key":"e_1_2_11_12_1","unstructured":"Colposcopic diagnosis treatment and follow up. Cervical screening: programme and colposcopy management. [cited 2021 08.12]. Available from:https:\/\/www.gov.uk\/government\/publications\/cervical\u2010screening\u2010programme\u2010and\u2010colposcopy\u2010management\/3\u2010colposcopic\u2010diagnosis\u2010treatment\u2010and\u2010follow\u2010up"},{"key":"e_1_2_11_13_1","unstructured":"Udredning behandling og kontrol af cervikal dysplasi (Diagnose treatment and active surveillance of cervical dysplasia) [cited 2021 08.20]. Available from:http:\/\/gynobsguideline.dk\/hindsgavl\/Cervixdysplasi2012.pdf"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10389-010-0330-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S208257"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12633"},{"key":"e_1_2_11_17_1","unstructured":"The Danish healthcare system [cited 2021 08.17]. Available from:https:\/\/www.sst.dk\/\u2010\/media\/Udgivelser\/2017\/Det\u2010danske\u2010sundhedsv%C3%A6sen\/Det\u2010Danske\u2010Sundhedsv%C3%A6sen \u2010d\u2010 \u2010Engelsk.ashx?la=da&hash=D93615E8EDEDF47D2D4FBC2473FD66E95D9D557A"},{"key":"e_1_2_11_18_1","unstructured":"PetersenLK SchrollJ DollerisBB et al. National klinisk retningslinje for celleforandringer p\u00e5 livmoderhalsen (National clinical guideline for cervical dysplasia)2019 Dansk Selskab for Obstetrik og Gyn\u00e6kologi."},{"key":"e_1_2_11_19_1","first-page":"420","volume-title":"Qualitative methods for health research","author":"Green J","year":"2018"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732315617444"},{"key":"e_1_2_11_21_1","first-page":"336","volume-title":"Interpretive description: qualitative research for applied practice","author":"Thorne S","year":"2016"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-019-0811-5"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.01.010"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-4-75"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-014-3074-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2013.06.021"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13462"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/0167482X.2016.1197905"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.09.001"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1355108"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.14354","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.14354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T16:14:01Z","timestamp":1741796041000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.14354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/aogs.14354"],"URL":"https:\/\/doi.org\/10.1111\/aogs.14354","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]},"assertion":[{"value":"2021-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}